腺相关病毒介导PSA基因转染DC的实验研究演示文稿.pptVIP

The immune system contains an arm with memory called the adaptive system, and an arm with no memory called the innate system. Lymphocytes are part of the adaptive system because they have memory. They remember specific antigens so that when they see the antigen again they can divide, proliferate and attack them again. B cells typically respond to extracellular pathogens whereas T cells typically respond to intracellular pathogens. Yet there is an important interdependence between the cells of the adaptive and the innate immune systems. The adaptive system cannot function without the innate system, but the innate system can function without the adaptive system. 腺相关病毒介导PSA基因 转染DC的实验研究 　　尤长宣 罗荣城 梁卫江　 　南方医科大学南方医院肿瘤中心 The Oncology Department of Nanfang Hospital, the Southern Medical University, Guangzhou Adaptive and Innate Immune Systems Skin Mucous Membranes rapidly regenerating surfaces, peristaltic movement, mucociliary escalator, vomiting, flow of urine/tears, coughing Cellular and Humoral Defenses lysozyme, sebaceous/mucous secretions, stomach acid, commensal organisms, complement proteins, phagocytosis, natural killer cells Invasion infection Barriers Innate immunity Adaptive immunity Inflammation Cellular and Humoral Defenses Antibodies, cytokines, helper T cells, cytotoxic T cells（CTL） MK-0069-01 Ag /MHC Class II Ag/ MHC Class I CD4 Activation Cytokines CD8 TARGET LYSIS Activation （CTL） Dendritic cell - MHC Class I restricted - antigen specific Antigen presentation Tumor antigen Antigen positive tumor cell Dendritic cells express a variety of cell surface molecules which play key roles in their interactions with T cells. The MHC molecules present antigenic fragments (peptides) to T cells in a form that can be recognized in a highly specific fashion by the appropriate T cell receptor, which is unique for every T cell and every antigen. The costimulatory molecules (CD80 and CD86) provide a second-signal that amplifies the antigen recogn