利用抗血小板聚集来治疗心血管疾病.pdf

R E V I E W S Antiplatelet therapies for the treatment of cardiovascular disease Alan D. Michelson Abstract | Antiplatelet therapy has been successful in reducing mortality and morbidity in acute myocardial infarction. Recent advances in understanding the molecular basis of the role of platelets in cardiovascular thrombosis have enabled the development of new agents with the potential to further reduce mortality and morbidity. This article reviews the role of platelets in haemostasis and cardiovascular thrombosis, and discusses the benefits and limitations of current and investigational antiplatelet agents in the treatment of cardiovascular disease. The most common cause of death in the developed world potent antiplatelet effect and less patient hyporespon- Acute myocardial infarction Popularly known as a heart is acute myocardial infarction, which is caused by coronary siveness; targeting new epitopes to try to improve oral attack, this is the death of artery thrombosis. Platelets have a central role in cardio- integrin αIIbβ3 antagonists; and the development of heart tissue from lack of vascular thrombosis. They adhere to the subendothelial agents directed against new platelet surface targets such oxygen, which is usually matrix after endothelial damage due to a ruptured as proteinase-activated receptor 1 (PAR1), platelet glyco- caused by a clot (thrombosis) in an artery that supplies atherosclerotic plaque, then aggregate with each other