红花黄色素注射液治疗脑梗死疗效及安全性的系统评价.DOCVIP

红花黄色素注射液治疗脑梗死疗效及安 全性的系统评价 李胜邓巧玲阮晓岚刘小平黄静宇孟详喻 武汉大学中南医院生物样本库武汉大学循证与转化 医学中心武汉大学中南医院检验科武汉大学人民 目的系统评价红花黄色素注射液治疗脑梗死的冇效性和安全性。方法检索电子 数据库搜集红花黄色素治疗脑梗死的随机对照试验，同时手工检索纳入的参考 文献。经过筛选、提取资料和评估风险偏倚后，采用Rev Man5. 3软件对符合纳 入标准的RCT进行Meta分析。结果共纳入38个RCT, 3454例患者。Meta分析 结果显示：(1)红花黄色素+常规治疗组总体有效率优于各对照组(单纯常规、 丹参、血栓通、川穹嗪、银杏达莫)，且差异具有统计学意义(P0. 05) ; (2)红 花黄色素对神经功能缺损评分改善程度优于对照组，差异具有统计学意义 [MD=-3. 14, 95%CI (-4.04, -2.24) , P0. 01] ; (3)红花黄色素组治疗后的中 医症候疗效评分平均低于对照组[MD=-3. 75, 95%CI (-5.41, -2.09) , P0. 01]; (4)在血液流变学、岀凝血功能指标、血清炎症标记物等方面，红花黄色素治疗 组的改善效果同样优于对照组(P0.05) ; (5)药物不良反应及毒副作用极少， 安全性较高。结论红花黄色素辅助治疗脑梗死可以有效地提高常规西药治疗效 果，且安全性良好，是目前较佳的治疗方案。同时，考虑到纳入研宂数量及质量 的限制，上述结论尚需更多高质量并采用关键性终点指标的临床试验予以验证。 关键词： 红花黄色素;脑梗死;系统评价;Meta分析; 基金：武汉大学“351人才计划” (2016年度)Safflower yellow for the treatment of cerebral infarction:a systematic review LI Sheng DENG Qiaoling RUAN Xiaolan LIU Xiaoping HUANG Jingyu MENG Xiangyu Biological Repositories， Zhongnan Hospital of Wuhan University; Department of Clinical Laboratory， Zhongnan Hospital of Wuhan University; Department of Hematology， Renmin Hospital， Wuhan University; Center for Evidencebased and Translational Medicine，Wuhan University; Abstract： Objective To evaluate the efficacy and safety of the safflower yellow injection in the treatment of cerebral infarction. Methods Related data published by December 2015 was retrieved from Pub Med, EMBASE, the Cochrane Library, VTP， CNKT, CBM and Wang Fang databases regarding randomized controlled tests (RCTs) about the safflower yellow injection in treating cerebral infarction. At the same time, related literature was retrieved manually. Two reviewers independently selected studies, extracted the data and assessed the risk of bias according to the inclusion and exclusion criteria. Meta-analysis of the included RCTs was performed with software Rev Man5. 3. Results A total of 38 RCTs involving 3454 patients were included. The results of meta analysis showed that (1) in terms of total efficiency, the safflower yellow injection combined with conv