[医学]普度大学发育生物学课件.ppt

Nodal Signaling Pathway FGF Signaling Pathway Limb Development (chick and mouse) Somite Development (chick, mouse and zebrafish) Wnt Signaling Pathway Cell lineage determination (worm) Mesoderm patterning (Frog) Limb bud development (chick and mouse) Somite Development (mouse) Bmp Signaling Body axis formation (Drosophila and frog) Mesoderm patterning (Drosophila and frog) Neural and non-neural ectoderm formation (Drosophila and frog) Cardiac Development (chick, mouse and zebrafish) Nodal Signaling Mesoderm pattern (Frog) Cardiac Development (chick, mouse and zebrafish) Notch Signaling pathway Cell lineage determination (Drosophila and Frog) Vulva Development (worm) Somite Development (chick, mouse and zebrafish) BIOL 595 Developmental Biology Fall 2010 8-24-10 Introduction Course Overview Pre-requests Textbooks Exam dates Grading School Policy The goal of this course is to… study the regulation of zygote development Zygote Fertilized egg Diploidy contains chromosomes of both male and female parents How does a single cell (zygote) transform into a complex organism? 2) Pluripotent – Potential of a cell to generate all cell types except extraembryonic tissue - Examples: embryonic stem cells and induced pluripotent stem (ips) cells 1) Totipotent – Ability of a single cell to divide and produce all the differentiated cells in an organism, including extraembryonic tissues Cell Plasticity- developmental potential 3) Multipotent – Potential of a cell to form several lineages within a tissue - Examples: Haematopietic stem cells and mesoderm Cell Plasticity-developmental Potential 4) Progenitor – Cell with the capacity to differentiate and divide but with limited self-renewal potential Cell Determination – Commitment to a lineage Commitment – Stable activation of a gene expression program characteristic of a lineage Cell Differentiation – Process by which cells become more specialized acquiring new identities - Cells of the same developmen