骨髓瘤硼替佐米耐药相关突变教学教材演示幻灯片.pptxVIP

MM硼替佐米相关突变2015-11-16NRAS、KRASPSMB5NF-κB通路持续活化相关HSP:HSP90 HSP27方法：MassARRAY? DNA质谱阵列基因分析NRAS-MUT: 1、硼替佐米单药耐药相关 2、PFS时间短 3、不影响硼替佐米联合大剂量DEX方案化疗的患者的预后Interestingly, KRAS but not NRASmutation was significantly associated with TP53 mutation (15% of those with KRAS mutation versus 3% of those without, P = 0.014).when we analyzed the impact of KRAS and NRAS mutations on survival separately, only KRAS and not NRAS mutations were significantly associated with shorter overall survival and progression free survival.体外实验：we here developed high levels (45- to 129-fold) of acquired resistance to bortezomib