空气污染与肾病教学教材演示幻灯片.pptxVIP

郑欢欢 JASN：在中国，空气污染可增加肾脏疾病风险 众所周知，空气污染会导致呼吸系统和心血管疾病，一项最新研究表明，它也有可能导致肾脏损伤。该研究发表在肾脏病顶级杂志——JASN上，呼吁关注空气污染对肾脏病发展的作用 J Am Soc Nephrol. 2016 Jun 30 J Am Soc Nephrol.  2016 Jun 30 INTRODUCTION Glomerular disease remains the leading cause of ESRD in Asia. Published studies have shown geographical and racial variations in the patterns of glomerular diseases. IgA nephropathy (IgAN) is the most common primary glomerulopathy in Asia, Europe, Australia, and some regions of the United States. No published studies have evaluated the effect of environmental factors on the changing pattern of glomerular diseases. J Am Soc Nephrol. 2016 Jun 30 China comprises 20% of the world population. With rapid developments in its economy and urbanization, especially during the past decade, air pollution has become a public health problemin some cities. Exposure to air pollution, especially particulate matter of＜2.5μm (PM2.5), has been associated with increased death and incidence of cardiovascular events. J Am Soc Nephrol. 2016 Jun 30 In this study, we analyzed data from an 11-year renal biopsy series including 71,151 patients from 938 hospitals in 282 cities across China, encompassing all age groups and both tertiaryand community hospitals, to evaluate secular pattern of glomerular diseases. We further examined the association between long-term exposure to PM2.5 and specific types of glomerular diseases. J Am Soc Nephrol. 2016 Jun 30 J Am Soc Nephrol. 2016 Jun 30 RESULTS J Am Soc Nephrol. 2016 Jun 30 J Am Soc Nephrol. 2016 Jun 30 J Am Soc Nephrol. 2016 Jun 30 From 2004 to 2014, the adjusted frequency of MN increased from 12.2% to 24.9% in this Chinese population. The risk for MN increased 13% annually in a regression analysis. Projected from this trend, MN would soon pass IgAN to become the leading type of nephropathy in China. J Am Soc Nephrol. 2016 Jun 30 Each 10 μg/m3 increase in PM2.5 concentration associated with 14% higher odds for MN (odds ratio, 1.14; 95% confidence inte