Loss of cell wall alpha glucan affects Cryptococcus…细胞壁α葡聚糖的流失影响隐球菌.pdfVIP

Molecular Microbiology (2007) 63(5), 1385–1398 doi:10.1111/j.1365-2958.2006.05551.x First published online 22 January 2007 Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence Amy J. Reese,1 Aki Yoneda,2 Julia A. Breger,3 morphological and biochemical investigations of the Anne Beauvais,4 Hong Liu,2 Cara L. Griffith,2 role of alpha glucan in the cryptococcal cell wall. Indrani Bose,2 Myoung-Ju Kim,2 Colleen Skau,2 Sarah Yang,2 Julianne A. Sefko,1 Masako Osumi,5 Jean-Paul Latge,4 Eleftherios Mylonakis3 and Introduction Tamara L. Doering2* Almost 40 years ago, researchers in Scotland detected 1Department of Biological Sciences, Cedar Crest a(1-3) glucan in the cell walls of several non-pathogenic College, Allentown, PA 18104-6196, USA. species of Cryptococcus (Bacon et al., 1968). Although 2 Department of Molecular Microbiology, Washington this polymer had been tentatively identified in other fungi in University School of Medicine, St Louis, MO 1952 (Duff, 1952), and was isolated from Aspergillus niger 63110-1093, USA. in 1965 (Johnson, 1965), several decades elapsed before 3 Division of Infectious Diseases, Massachusetts General a protein was implicated in its synthesis. Studies of the Hospital, Boston MA 02114-2606, USA. non-pathogenic fission yeast Schizosaccharomyces 4 Unite des Aspergil