Research Article Dietary Blueberry and Bifidobacteria…研究论文饮食蓝莓和双歧杆菌.pdfVIP

Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2014, Article ID 469059, 12 pages /10.1155/2014/469059 Research Article Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway Tingting Ren,1 Chao Huang,2 and Mingliang Cheng3 1 Biochemistry Department, Ailiated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, China 2 Guiyang Medical College, Guiyang, Guizhou 550004, China 3 Department of Infectious Diseases, Ailiated Hospital of Guiyang Medical College, 28 Guiyi Street, Guiyang, Guizhou 550004, China Correspondence should be addressed to Mingliang Cheng; minglianggy@163.com Received 22 August 2014; Revised 1 November 2014; Accepted 3 November 2014; Published 27 November 2014 Academic Editor: Cinzia Signorini Copyright 漏 2014 Tingting Ren et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. NAFLD model rats were established and divided into NAFLD model (MG group), SIRT1 RNAi (SI group), blueberry juice (BJ group), blueberry juice + biidobacteria (BJB group), blueberry juice + SIRT1 RNAi (BJSI group), and blueberry juice + biidobacteria + SIRT1 RNAi groups (BJBSI group). A group with normal rats was a control group (CG). BJB group ameliorated NAFLD, which was better than BJ group (肀 0.05). he lipid accumulation was lower in CG, BJ, and BJB groups than that in MG, SI, BJSI, and BJBSI groups (肀 0.05). he levels of SIRT1 and PPAR-砘 were higher in CG, BJ, and BJB groups than those in MG, SI, BJSI, and BJBSI groups (肀 0.05). he levels of SREBP-1c were