心力衰竭的细胞分子生物学基础：PKC激活和心力衰竭-英文课件精选.pptVIP

 Wei DUANSchool of MedicineDeakin UniversityMelbourne, Australia Heart Failure in Australia The prevalence of heart failure in Australia is ~6.3% . The heart failure prevalence is 10% in people aged over 65 years (this population will double over the next 50 years in Australia). wo Nature Medicine, 10:239,2004 Most available kinase inhibitors are ATP-binding site analogues Study of the function of C-terminus of PKC-alpha The last 10 amino acid residues are essential for the catalytic competence of PKC-alpha The critical role of the very C-terminus of PKC-a in the activation of MAPK Targe