downstream drug product processing of itraconazole nanosuspension factors influencing drug particle size and dissolution from nanosuspension-layered beads：（下游药品处理伊曲康唑nanosuspension药物粒径影响因素和解散nanosuspension-layered珠子）.pdfVIP

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downstream drug product processing of itraconazole nanosuspension factors influencing drug particle size and dissolution from nanosuspension-layered beads：（下游药品处理伊曲康唑nanosuspension药物粒径影响因素和解散nanosuspension-layered珠子）.pdf

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downstream drug product processing of itraconazole nanosuspension factors influencing drug particle size and dissolution from nanosuspension-layered beads：（下游药品处理伊曲康唑nanosuspension药物粒径影响因素和解散nanosuspension-layered珠子）

International Journal of Pharmaceutics 524 (2017) 443–453 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsev /locate/ijpharm Downstream drug product processing of itraconazole nanosuspension: Factors inﬂuencing drug particle size and dissolution from nanosuspension-layered beads a b c,* d Johannes Parmentier , En Hui Tan , Ariana Low , Jan Peter Möschwitzer a Gustav Parmentier GmbH, Eichendorffstr. 37, 60320 Frankfurt am Main, Germany b AbbVie Pte Ltd, Research and Development, 9 North Buona Vista Drive, The Metropolis Tower One #19-01, Singapore 138588, Singapore cAbbVie GmbH Co. KG, Knollstrasse 50, 67061 Ludwigshafen, Germany d Department of Pharmaceutical Technology, Biotechnology and Quality Management, Free University of Berlin, 14195 Berlin, Germany A R T I C L E I N F O A B S T R A C T Article history: Received 8 December 2016 There is more research required to broaden the knowledge on the downstream processing of Received in revised form 4 April 2017 nanosuspensions into solid oral dosage forms, especially for coated nanosuspensions onto beads as Accepted 5 April 2017 carriers. This study focuses on bead layering as one approach to solidify nanosuspensions. The aim was to Available online 8 April 2017 systematically investigate the inﬂuence of type of coating polymer (HPMC VLV vs. copovidone), bead