【麻醉学精品教学课件】Anesthetics教学资料讲义教学资料讲义.pptVIP

Chapter 1 Anesthetics;Local anesthetics General anesthetics;Local anesthetic is used on specific nerve pathways , has effect of a loss of awareness of a part of the body. Whreas general anesthetic is used on central nervous system, has effect of a total unconsciousness. ;1.1.1 Discovery and development of local anesthetics; Physical properties: white crystal or crystalline powder, odorless, bitter taste and then a sense of paralysis. Mp.154 ~ 157 ℃. Soluble in water (1:1), slightly soluble in ethanol (1:30) and chloroform, hardly soluble in ether. ;Synthesis of Procaine;Aromatic acid est