(精选)【医学课件课件】肠道病毒与轮状病毒教学课件.pptVIP

Individuals with paralytic polio will experience: Tremors Muscle weakness Fever Stiffness Constipation Muscle pain and spasms Difficulty swallowing 预防 口服脊髓灰质炎减毒活疫苗糖丸(1957年发明） Oral vaccination with live vaccine Vaccination programs have eradicated it from the Western world and promise to eliminate it globally Dr Alber Sabin Polio virus Nervous system: Polio is a virus that infects the nervous system of humans (only) Paralysis: It can cause temporary or permanent paralysis or death Vaccine :There is a vaccine for polio Eradicate :The World Health Organization plans to eradicate polio in the next decade Continue: Polio outbreaks continue to occur in areas in which many are not vaccinated Since vaccine has become widespread in the United States, cases of polio are rare. However, polio remains a problem in many parts of the world. ? 肠道病毒 Poliovirus infects human cells by binding to an immunoglobulin-like receptor, CD155, (also known as the poliovirus receptor (PVR) on the cell surface Poliovirus is a positive stranded RNA virus. Thus the genome enclosed within the viral particle can be used as messenger RNA and immediately translated by the host cell. Poliovirus uses two key mechanisms to evade the immune system. First, it is capable of surviving the highly acidic conditions of the gastrointestinal tract, allowing the virus to infect the host and spread throughout the body via the lymphatic system. Second, because it can replicate very quickly, the virus overwhelms the host organs before an immune response can be mounted.[5] Immune system avoidance 学习要求 掌握 1、脊髓灰质炎病毒的致病性 2、特异性预防（剂型） 自学柯萨奇病毒 3、熟悉脊髓灰质炎病毒抵抗力、感染类型 自学埃可病毒 polio virus For decades, no one knew what poliovirus looked like, since viruses cannot be seen under a microscope. In 1985, a team led by James Hogle of Harvard Medical School obtained high-resolution, 3D images of poliovirus, and today, the newly formed Childrens Hospital Boston -- Harvard Medical School structural biology unit is h