(精编)【医学教学课件大全】 New Research Field in Molecular Biology教学课件.pptVIP

Chapter 8 New Research Field in Molecular Biology ;8.1 Bioinformatics;What is bioinformatics? Bioinformatics and computational biology involve the use of techniques including applied mathematics, informatics, statistics, computer science, artificial intelligence, chemistry, and biochemistry to solve biological problems usually on the molecular level. ;2. Major research fields (1) Sequence analysis (3) Computational evolutionary biology (4) Measuring biodiversity (5) Analysis of gene expression (6) Analysis of regulation (7) Analysis of protein expression (8) Analysis of mutations in cancer (9) Prediction of protein structure (10) Comparative genomics (11) Modeling biological systems (12) High-throughput image analysis;Proteomics is the systematic study of all of the proteins in a cell, tissue, or organism. The analysis includes the identification, expression, localizations, functions (physiological and pathophysiological functions), and interactions of proteomes.;4. Branches of Proteomics;Protein Microarrays;蛋白质芯片的意义;一种蛋白质的所有变异体 一个蛋白质家族的所有成员 一条信号通路中的所有蛋白质 一种组织、器官或有机体的所有蛋白质 ;Different Kinds of Protein Arrays;;蛋白质芯片检测;蛋白质芯片的应用;Problems;Functional Proteomics (in vitro);In silico methods (bioinformatics) Genome-wide Protein Tagging Genome-wide Gene Deletion or Knockouts Random Tagged Mutagenisis or Transposon Insertion Yeast two-hybrid Methods Protein (Ligand) Chips;Structural Proteomics;Structural Proteomics: The Goal;Why Structural Proteomics?;Bioinformatics Proteomics;8.3 Metabonome Metabonomics;1. What is Metabonome ? - It refers the complete set of metabologically regulated elements in cells. ;2. What is Metabonomics Metabonomics is the branch of science concerned with the quantitative understandings of the metabolite complement of integrated living systems and its dynamic responses to the changes of both endogenous factors and exogenous factors. ;代谢组学的中心任务： ? 对内源性代谢物质的整体及其动态变化 ? 对规律进行检测，量化和编录 ? 确定此变化规律和生物过程的有机联