(精编)C.elegans and microRNAs (线虫和microRNAs )教学课件.pptVIP

C. elegans as a Model System;Developed by Sydney Brenner (1963) Mutants published by Brenner (1974) 1976 postembryonic cell lineages determined (Sulson and Horwitz) 1983 complete embryonic cell lineages determined (Deppe et al., Sulson et al.) 1982 Programmed cell death (Horwitz et al.) Nobel Prize Brenner, Sulson, Horwitz 2002 1986 Complete connectivity of nervous system established (White et al.) The mind of a worm” 1991-98 RNAi and miRNA discovered in worms. Nobel Prize: Fire, Mello 2006 1998 First animal genome sequenced (97Mb, now 100.3Mb). This is about 1/30 the size of the huma