抗生素英文课件精品 ANTIBIOTICS幻灯片课件.ppt

ANTIBIOTICS;CONTENTS;;BIBILOGRAPHY;;MODERN ERA; THIS IS THE MOST DRUGGED GENERATION THE MYTH A PILL TO CURE EVERY ILL; RATIONALE OF DRUG USE; PATTERNS OF MISUSE;*Overuse in situations in which pt’s are not at risk for metastatic infections. *Treatment of chronic adult periodontitis almost totally amenable to mechanical therapy. *Administration instead of mechanical therapy for periodontitis. * Long term administration in th management of periodontal disease. *Antibiotic therapy instead of incision drainage. *Administrations to avoid claims of negligence. * Administrations in improper situations, dosage duration of therapy. ;DRUG LEGISLATIONS;;;;BACTERIAL GROWTH CURVE;ANTIBIOTIC MECHANISM OF ACTION ;;;;;PRINCIPLES OF ANTIBIOTIC DOSING;MICROBIAL DRUG RESISTANCE;;SULFONAMIDES;ANTI BACTERIAL SPECTRUM Primarily bacteriostatic agent against many gram+ve gram_ve bacteria. Organisms still sensitive are St.pyogenes,H.influenzae,H.ducreyi,E.coli, V.cholera,Chalydiae,Actinomyces,Nocardia Toxoplasma.;USES;ADVERSE EFFECTS;COTRIMOXAZOLE;USES:;ADVERSE EFFECTS:;FLOUROQUINOLONES;FLOUROQUINOLONES;CIPROFLOXACIN;Remarkable microbiological features of ciprofloxacin other FQ’s include Rapidly bactericidal highly potent. Relatively long PAE. Low freq. Of mutational resistance Protective streptococci anaerobes are spared Active against B- lactams aminoglycoside resistant bacteria Less active against acidic pH. PHARMACOKINETICS: Rapidly absorbed orally but food delays absorption. First pass metabolism occurs. High tissue penetrability. Excreted primarily in urine.;INTERACTIONS:;ADVERSE EFFECTS:;CEPHALOSPORINS;3rd generation Cefotaxime Cefoperaxone Ceftriaxone Ceftazidime Cefixime Cefdinir;;USES;ADVERSE EFECTS:;CHLORAMPHENICOL;PHARMACOKINETICS;USES;ADVERSE EFFECTS;AMINOGLYCOSIDES;PRECAUTIONS INTERACTIONS;STREPTOMYCIN;USES;MACROLIDES;SPECTRUM;USES;ADVERSE EFFECTS;MISCELLANEOUS