最优刺激序列.docVIP

采用改进DE算法优化高刺激率AEP的刺激序列( 黄江华 李 彬 林 霖 朱 程 王 涛* (南方医科大学生物医学工程学院，广州，510515) 摘要：刺激序列的性质直接影响高刺激率听觉诱发电位（Auditory evoked potentials, AEP）去卷积的性能，自动生成满足需求的刺激序列可以为高刺激率AEP的基础和应用研究带来极大便利。本文以刺激序列的抖动量为优化变量利用差分进化（Differential evolution, DE）算法定义了约束条件下的目标函数。我们根据抖动量的变化范围，改进了DE搜索的变异算子实现搜索空间动态缩减。该方法可以方便地生成各种参数（包括刺激率、频带范围、扫程长度和采样频率）的低抖动率刺激序列。通过实测脑电信号合成的数据检验，本方法得到的各种刺激序列都取得了较好的效果。 关键词：差分进化算法；去卷积；听觉诱发电位 中图分类号： R318 Optimizing stimulus-sequences of the high-rate AEP using modified differential evolution algorithm Huang Jianghua, Li Bin, Lin Lin, Zhu Cheng, Wang Tao (School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China) Abstract: In the study of auditory evoked-potentials (AEPs) under high stimulus rate paradigm, the generation of appropriate stimulus sequences in an automatic way will facilitate the research and application of such paradigm. This paper presents a method to obtain the applicable stimulus-sequence using a modified differential evolution (DE) algorithm. By defining an objective function in terms of jitter ratio (JR) and underlying constraint condition derived from the spectrum of the sequence, the method is able to gradually reduce the searching-space guaranteed by a dynamic scaling factor in the mutation process of the DE algorithm. Four compatible sequences are given to make comparisons with the manual selected sequences as reported. The performance evaluated by the synthetic data justifies the feasibility of the present method. Key words: differential evolution (DE) algorithm; deconvolution ; auditory evoked-potential(AEP) 引言 听觉诱发电位（Auditory evoked potentials , AEP）是听觉系统受到声音刺激后中枢神经系统产生的与外界刺激相关的生物电反应。其刺激方式主要采用刺激间隔（Stimulus onset asynchrony, SOA）相等的刺激声多次重复作用于听觉系统。这种方式的刺激率（= 1/SOA）较低，当刺激率提高使刺激序列的间隔小于诱发反应的潜伏期时就会出现相邻诱发反应首尾重叠而无法分辨的现象，这在工程学上可视为单个刺激声所诱发的暂态AEP与刺激序列的循环卷积。基于这一模型，如果对刺激序列中的SOA采用抖动技术，即SOA取一定范围内的随机数，通过去卷积计算可以重建暂态AEP。这种计算方法在一些文献中习惯上被称为连续循环平均去卷积（Continuous loop average deconvolution, CLAD）方法[1-4]。