线粒体功能紊乱与胰岛素抵抗.pdfVIP

线粒体功能紊乱与胰岛素抵抗 马慧娟 宋光耀 [摘要]胰岛素抵抗是2型糖尿病的重要发病机制，而骨骼肌线粒体功能紊乱与胰岛素抵抗密 切相关，遗传、环境、衰老以及氧化应激可以导致线粒体功能紊乱。胰岛素抵抗者伴有线粒体功能下 降，通过运动或减重等手段改善胰岛素敏感性的同时，线粒体功能也得以改善，其机制可能与线粒体 功能异常通过抑制胰岛素受体底物-l活性、干扰胰岛素信号转导系统有关。 胰岛素抵抗；线粒体功能；2型糖尿病 Mitochondrial disfunction and insulin resistance MA Hui-juanSONG Guang-yao Department of Endo crinology , The General Hospital of Hebei ,Shijiazhuang 050051, China [ Abstract] Insulin resistance is the important pathogenesis of type 2 diabetes,while skeletal muscle mitochondrial disfunction is closely related with insulin resistance. Genetic factors, environmental factors, aging, and oxidative stress can induce insulin resistance. lndividnals with insulin resistance have mitochondri al dysfunction. Exercise or weight loss can increase insulin sensitivity and improve mitochondrial dysfunction. The mechanism may be related to that mitochondrial dysfunction inhibits the activity of insulin receptor substrate-1 ,interfere with insulin signaling system. Insulin resistance;Mitochondrial function;Type 2 diabetes mellitus 10. 3760/cma. j. issn. 1673-4157. 2011.05. 011 河北省自然科学基金资助项目( C2008001293) 050051石家庄，河北省人民医院内分泌二科 3 in the pathophysiology of skeletal muscle insulin resistance. En docr Rev,2010,31:25-51. @@[ 12] Holloszy JO. Skeletal muscle mitochondrial deficiency does not mediate insulin resistance. Am J Clin Nutr,2009,89:463S-466S. @@[ 13 ] Nai