《谢瑞满-骨质疏松症(eng)》.pptVIP

Chapter 28 Osteoporosis Presentation: 2005 谢瑞满 Rui-man Xie，Ph.D., M.D. Professor of Neurology Gerontology ZhongShan Hospital, Fudan University rmxie@, xieruiman@ Objective 1、Definition、types and mechanism of osteoporosis2、 Diagnosis、prevention and treatment of osteoporosis 3 、Etiology and Epidemiology of osteoporosis times – 45 minutes×2 Overview Definition : Osteoporosis is a bone disease in which the amount of bone is decreased and the structural integrity of trabecular bone is impaired. Cortical bone becomes more porous and thinner. This makes the bone weaker and more likely to fracture. figures Associated changes in body shape and vertebra （deleted 6 pictures） Patients with risk factors or conditions that cause osteoporosis Postmenopausal woman with family history of hip fractures or kyphosis Medications: corticosteroids, dilantin, gonadotropin releasing hormone agonists, loop diuretics, methotrexate, thyroid, heparin, cyclosporin, depot-medroxyprogesterone acetate Hereditary skeletal diseases: osteogenesis imperfecta, rickets, hypophosphatasia Endocrine and metabolic: hypogonadism, hyperparathyroidism, hyperthyroidism, Cushing syndrome, acidosis, Gauchers disease Marrow diseases: myeloma, mastocytosis, thalassemia Others: Anorexia, Malabsorption, Cystic fibrosis, Renal insufficiency, Hypercalciuria, Hepatic disease, Depression, Spinal cord injury, Systemic Lupus, Weight below healthy range, Cigarette smoking Epidemiology The population of older men and women has been increasing, and therefore the number of people with osteoporosis is increasing. In the USA, about 21% of postmenopausal women have osteoporosis (low bone density), and about 16% have had a fracture. In women older than 80, about 40% have experienced a fracture of the hip, vertebra, arm, or pelvis. Women have more osteoporotic fractures than men. Age is one of the most important risks in all groups. The decreased