高分子Preparationofsuppositories－孙敏捷.pptVIP

Department of Pharmaceutics, China Pharmaceutical University 2011-5-6 Preparation of suppositories Purposes To know the characters and applications of the bases of suppositories. 2. To master the characters and applications of fusion method to prepare suppositories. Introduction Suppositories: are preparations made by incorporating medicaments in suitable bases, intended for rectal administration. vaginal suppository and rectal suppository Bases of suppository : greasy bases Cocoa butter water-soluble bases Glycerol-gelatin, PEG Preparing method: fusion method Introduction Procedures 1. Glycerol suppository (1) Formulation: Glycerol 8g Sodium carbonate 0.2g Stearic Acid 0.8g Distilled water 1g Procedures (2) Preparation NaCO3,H2O glycerol water bath add stearic acid slowly clear solution stirring boiling , bubble pour into the molds cooling, trimming final products Chlorhexidini Acetas suppository (1) Formulation: Chlorhexide Acetate 0.05g Tween 80 0.2g Borneol ethanol 0.5mL Glycerol 9.0g Gelatin 2.7g Distilled water add up to 20.0g Procedures Procedures (2) Preparation gelatin,20mLH2O add glycerol gelatin dissolve water bath weight of mixture is 18-20g swell for 30min keep heating chlorhexide acetate in tween 80 borneol ethanol ﹜ mix add mixture above pour into the molds cooling, trimming final products Procedures (2) Preparation Result ? Questions 1. What are the principles of preparation and precautions in the preparation of glycerol suppository? 2. What is the mechanism of action of glycerol suppository? 3. What are the characteristics of glycerin-gelatin base in suppositories? Thank you !