3.0tmrdwi和mrs在宫颈癌诊疗中的价值分析 word格式.docxVIP

Part IIEvaluation of Cervical Cancers by Proton Magnetic Resonance Spectroscopy at Three Tesla[Abstract] Objective To evaluate the characteristics with in vivo proton magnetic resonance spectroscopy of cervical cancers, and to investigates diagnostic value of single voxel magnetic resonance spectroscopy in cervical cancers.Methods. 35 patients with cervical cancer and 6 cases of healthy volunteers were were examined in a whole-body 3.0 T clinical magnetic resonance scanner. Single voxel spectroscopy (SVS) was undertaken after identification of lesions on T2-weighted imaging. Of which 5 patients with cervical cancer after chemotherapy were examined again. Results MRS were performed successfully in 30 cases. There were Cho in all cervical cancer (30/30, 100 %), Cr in 27 cases(27/30, 90%), Lac in 4 cases(4/30, 13.3%) and there were Lip in 25 cases(25/30, 83.3%). After chemotherapy, 2 cases of tumor volume increase than before, Cho was higher than before, and one case of tumor regression, Cho and Lip were decreased, 2 cases were no significant change.Conclusion 3.0T magnetic resonance spectroscopy for cervical cancer provides a molecular lesion in vivo metabolism of a new means of using . Cho peak detection of cervical cancer during treatment may reflect the molecular changes in metabolism.[key words] Uterine cervical cancer;magnetic resonance imaging; magnetic resonance spectroscopy独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成 果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或 集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文 中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保 留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本 人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索， 可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。本论文属于保密□ ，在年解密后适用本授权书。不保密□。（请在以上方框内打“√” ）学位论文作者签名：指导教师签名：日期：年月日日期：年月日前言宫颈癌是女性生殖系统最常见的肿瘤之一，其发病率居女性生殖系统恶性肿瘤首 位，是女性生殖系统恶性肿瘤死亡的主要原因之一[1]。近年来, 随着宫颈癌发病年龄 的年轻化、宫颈癌病理类型的改变, 以及年轻患者对保留卵巢与治疗后生活质量要求 的提高，对宫颈癌的治疗提出新的挑战[2]。以往，宫颈癌的常规治疗以放射治疗和手 术治疗为主。而近年来，新辅助化疗(Neoadjuvent chemo- therapy