aihaevans综合征患者外周血淋巴细胞cd80和cd86的表达及其意义 word格式.docxVIP

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aihaevans综合征患者外周血淋巴细胞cd80和cd86的表达及其意义 word格式.docx

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aihaevans综合征患者外周血淋巴细胞cd80和cd86的表达及其意义 word格式

ABSTRACT【Abject】Detected the expression rates of costimulatory molecules CD80 and CD86 on peripheral blood lymphocytes (PBLs) from patients with autoimmune hemolytic anemia (AIHA)/Evans syndrome(which erupts simultaneously at the same time /or/or afterwards AIHA), and compared with post treatment group and control group, and study their mechanisms of cellular immune function disorder and significance in AIHA/Evans syndrome.【Methods】Data were collected from 13 patients with AIHA/Evans syndrome from February 2010 to February 2011 in YueBei People’s Hospital affiliated to Shantou University Medical College，the median age was 47 years old(19 to 72 years old), 6 males and 7 females, and 13 cases of normal controls, the median age was 45 years old(20 to 68 years old), 6 males and 7 females. And among the 13 AIHA/Evans syndrome patients ， 4 cases who were treated was post treatment group. By Facs，the expression rates of CD80 and CD86 on PBLs of 13 cases with AIHA/Evans syndrome,13 normal controls and 4 post treatment cases were detected. Statistical analysis was executed by SPSS17.0 software, a value less than 0.05 was considered as significance.【Results】The expression rate of CD80 on PBLs of AIHA/Evans syndrome group was lower after treatment than before (1.37±0.82)% VS (7.38±8.69)%(P0.05)，both of which were not significant different with control group, (1.37±0.82)% VS (0.90±0.48)%(P0.05)and (7.38±8.69)% (P0.05) respectively.The expression rate of CD86 on PBLs of AIHA/Evans syndrome group was lower after treatment than before (3.41± 2.62)% VS (11.45± 10.91)% (P0.05)， both of which were not significant different with the control group, (3.41 ± 2.62)% VS (1.92 ± 0.93)% (P0.05) and (11.45±10.91)% VS (1.92±0.93)% (P0.05) respectively.The expression rates of CD80 and CD86 on PBLs were not associated with the age, sex, hemoglobin (Hb) concentrations and indirect bilirubin(IBIL)concentrations, absolute value of reticulocyte (Ret#).【Conclusions】The expression rates of CD80 and CD