pmp诊治进展 课件.pptVIP

腹膜假性粘液瘤临床诊治研究进展;;;腹膜假性粘液瘤的起源——阑尾;腹膜假性粘液瘤——粘液;腹膜假性粘液瘤——大网膜;腹膜假性粘液瘤——腹膜;腹膜假性粘液瘤——肠管及系膜;PMP病理分类尚有争议;;Early- and Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Treated by a Strategy of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. J Clin Oncol. 2012 Jul 10;30(20):2449-56. ;;PMP临床特点; 目前的研究结果认为肿瘤减灭术+腹腔热灌注化疗（CRS+HIPEC）是有效的治疗方式，5年生存率可达50%-80%;Early- and Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Treated by a Strategy of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. J Clin Oncol. 2012 Jul 10;30(20):2449-56. ;PMP诊治进展;一 病灶切除程度分类：CC评分; CC评分是用来评估肿瘤是否肉眼完全 切除的指标，根据肿瘤残留程度分为4级 CC-0 无肉眼可见的肿瘤残留 CC-1 残留肿瘤直径0.25cm CC-2 残留肿瘤直径为0.25-2.5cm CC-3 残留肿瘤直径2.5cm 腹膜假性粘液瘤完全切除的标准是 CC-0，CC-1 ;图例 — CC-0 — CC-1 — CC-2 — CC-3;二 HIPEC的适应证 ;不同切除程度联合HIPEC的疗效;PMP行HIPEC的适应证;三 指导病灶切除程度的指标; 彻底减瘤与手术安全的冲突; 来源于回顾分析，缺乏临床随机对照研究;四 HIPEC的药物选择 ;HIPEC的药物选择原则;HIPEC的药物选择;五 PMP的基因研究 ;PMP较为常见的几种突变类型;Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei. PLoS One. 2017 Apr 20;12(4):e0174898;Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei. PLoS One. 2017 Apr 20;12(4):e0174898;Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei. PLoS One. 2017 Apr 20;12(4):e0174898;结语及展望;Thank You !