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ASHP Guidelines on Medication-Use Evaluation Medication-use evaluation (MUE) is a performance improve- ment method that focuses on evaluating and improving medi- cation-use processes with the goal of optimal patient outcomes. MUE may be applied to a medication or therapeutic class, dis- ease state or condition, a medication-use process (prescribing, preparing and dispensing, administering, and monitoring), or specific outcomes.1 Further, it may be applied in and among the various practice settings of organized health systems. MUE encompasses the goals and objectives of drug- use evaluation (DUE) in its broadest application, with an emphasis on improving patient outcomes. Use of “MUE,” rather than “DUE,”2 emphasizes the need for a more mul- tifaceted approach to improving medication use. MUE has a common goal with the pharmaceutical care it supports: to improve an individual patient’s quality of life through achievement of predefined, medication-related therapeutic outcomes.3,4 Through its focus on the system of medication use, the MUE process helps to identify actual and potential medication-related problems, resolve actual medication- related problems, and prevent potential medication-related problems that could interfere with achieving optimum out- comes from medication therapy. In organized health systems, MUE must be conducted as an organizationally authorized program or process that is proactive, criteria based, designed and managed by an inter- disciplinary team, and systematically carried out. It is con- ducted as a collaborative effort of prescribers, pharmacists, nurses, administrators, and other health care professionals on behalf of their patients. MUE Objectives Some typical objectives of MUE include ? Promoting optimal medication therapy. ? Preventing medication-related problems. ? Evaluating the effectiveness of medication therapy. ? Improving patient safety. ? Establishing interdisciplinary consensus on medica- tion-use processes. ? Stimulat