普伐他汀对不稳定型心绞痛患者血清hs-CRP水平影响.docVIP

普伐他汀对不稳定型心绞痛患者血清hs-CRP水平影响 　　[摘要] 目的 探讨不稳定型心绞痛（UAP）患者血清超敏C反应蛋白（hs-CRP）水平变化及普伐他汀对其的影响。方法将40例UAP患者随机分为常规治疗组20例，普伐他汀治疗组20例，观察治疗8周前后血清hs-CRP水平的变化。其中血清hs-CRP测定采用免疫透射比浊法。结果 两组患者的年龄、性别、吸烟史、血压、血糖、血脂水平无显著性差异（P＞0.05）；治疗前两组血清hs-CRP水平无显著性差异[（14.61±4.30）mg/L vs （14.23±6.21）mg/L，P＞0.05]；治疗8周后常规治疗组与普伐他汀治疗组血清hs-CRP水平较治疗前明显降低，两组间比较有显著明显性差异[（12.01±5.10）mg/L vs （8.81±6.32）mg/L，P＜0.05]。结论 不稳定型心绞痛患者血清hs-CRP水平升高，表明不稳定型心绞痛患者存在易损斑块。作为易损斑块的血清学标志物，可能在不稳定性心绞痛的早期诊断和预测中有重要的临床意义；不稳定型心绞痛患者的常规治疗在一定程度上可以提高动脉斑块的稳定性，加用普伐他汀后可进一步稳定动脉斑块。 　　[关键词] 不稳定型心绞痛；易损斑块；超敏C反应蛋白；普伐他汀 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701（2011）33-35-03 　　 　　The Effect of Pravastatin on the Levels of High-seneitivity C-reactive Protein in Patients with Unstable Angina Pectoris 　　XIA Lizhi GAO Zhenjun 　　Harbin 242 Hospital in Heilongjiang Province, Harbin 150066, China 　　 　　[Abstract] Objective To discuss the effect of pravastatin on the serum levels of high-seneitivity C-reactive protein in patients with unstable angina pectoris. Methods Fourty patients with unstable angina pectoris were randomly divided into conventional therapeutic group （n=20） and pravastatin therapeutic group （n=20）. The serum levels of high-seneitivity C-reactive protein were assayed before and 8 weeks after treatment in the two groups. hs-CRP levels were measured by quantitative sandwich enzyme immunoassay assay. Results There were no significant difference between the two groups in age, sex, the smoking history, blood pressure, blood glucose and blood cholesterol levels （P＞0.05）; Before the treatment, there was no significant difference between the two groups in the levels of serum hs-CRP[（14.61±4.30）mg/L vs （14.23±6.21）mg/L，P＞0.05]; After 8 weeks of treatment, there was obvious decrease in the levels of serum hs-CRP between the two groups and the difference of two groups was significant[（12.01±5.10）mg/L vs （8.81±6.32）mg/L, P＜0.05]. Conclusion The levels of serum hs-CRP were increased in unstable angina pectoris, which indicated that there were