节律收缩扩张下肺腺泡内流场特性及细颗粒物沉积的数值模拟研究-供热、供燃气、通风及空调工程专业论文.docx

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节律收缩扩张下肺腺泡内流场特性及细颗粒物沉积的数值模拟研究-供热、供燃气、通风及空调工程专业论文.docx

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节律收缩扩张下肺腺泡内流场特性及细颗粒物沉积的数值模拟研究-供热、供燃气、通风及空调工程专业论文

TheNumericalSimulation ResearchonAirflowPatternsand Micro-particleDepositionin thePulmonaryAcinuswith RhythmicWallContraction/ExpansionSpecialty:Heating,GasSupplying,VentilationandAir ConditioningName:LiFeiInstructor: Prof.ZhangHong-yan,A/P.CuiHai-hangAbstractDuringthelongperiodofevolution,thehumanbodyhasestablishedacomplexbifurcatepipelinesystemwiththemagnitudeorderofμm~mmforsubstancestransportation.Ithasacomplexoperationalmechanism,thusensuringitsefficientmasstransportfunction.Respiratorysystemforgastransportandbloodcirculationsystemforliquidtransportmeetinthepulmonaryacinus.Here,airflowpatternsarevariedandthemechanismisquitecomplex.Especially,apartofmicro-particlecarriedby airflowcanflowintorespiratorysystemanddepositeinthepulmonaryacinus,andevenpenetrateintobloodcirculationsystemthroughair-bloodbarrier.Then,thesemicro-particlescirculateinthewholebody.Therefore,itisthepulmonaryacinusthathasaspecialstatusinhumanbodyandsignificant researchvalue.Atthisstage, theresearchof thepulmonary acinusisfocusedonitslocalproperty,onlymodelingasinglealveolusorasinglealveolatedductgeometrically.However,thegeometricmodelsindomesticstudieswhichtakeintoaccountbothlocalpropertyandglobalpropertyhasn’tappeareduptonow.Afterstudyinggreatamountofresearchathomeandabroad, thewholepulmonaryacinus2Dand3DmodelareestablishedbasedonWeibelAmodelwithreasonableassumptionsandsimplifications.Thetwomodelsadopttheideaofflowassignment.Afterestablishingthewholepulmonaryacinus2Dand3Dmodel,themultiphysicsnumericalsimulationsoftwareCOMSOLisusedtoanalyse andstudyairflowpatternsunder threeunsteady breathingscenarios—sedentarytidalvolume(TV)breathing,inspiratorycapacity(IC)breathing,andhighfrequencyoscillation(HFO)breathing.Particledepositionrules ofsix sizesparticlesrangingfrom西安建筑科技大学硕士学位论文0.01to3micronswasobserved.Thatalveolarrhythmiccontraction/expansionisthemainreasonforairflow,somovingmeshisusedtogetalveolarwallsmoving,andthismakesthebiologicalphenomenonrealistic.The researchonairflowpatternsofpulmonarya