有机纳米粒子制备、表面功能化及其生物应用-无机化学专业论文.docxVIP

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有机纳米粒子制备、表面功能化及其生物应用-无机化学专业论文.docx

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有机纳米粒子制备、表面功能化及其生物应用-无机化学专业论文

目录第一章：绪论···················································································11.1 荧光纳米探针用于活体肿瘤成像概述···········································11.1.1 有机染料的载体纳米颗粒··················································21.1.2 近红外量子点QDs81.1.3 聚集态荧光增强荧光染料·················································111.1.4 上转换纳米材料（UCNPs）141.2多功能组合诊疗·····································································201.2.1 诊疗概念及现状·····························································201.2.2 化疗与光成像组合··························································211.2.3 化疗与磁共振成像组合····················································231.2.4 化疗与热疗组合治疗·······················································251.3 载体装载系统机遇与挑战·························································271.4课题的选题思路以及主要内容···················································29第二章：超亮的，超稳定的近红外染料纳米颗粒在生物体外，体内的生物成像312.1引言···················································································312.2实验部分··············································································322.3结果与讨论···········································································362.3.1 NPAPF NPs的合成与表征363.3.2 NPAPF纳米颗粒的光学性质36NPAPF NPs的表面修饰37NPAPF NPs的毒性38NPAPF NPs的光稳定39NPAPF NPs的主动靶向细胞成像40NPAPF NPs-PEG体内成像，循环和组织分布412.4结论···················································································43第三章：多功能诊疗药物纳米颗粒制备及癌症治疗研究·····························453.1背景···················································································453.2 实验部分··············································································473.3结果与讨论···········································································513.3.1 纳米棒的制备，表征和表面修饰········································51NR-PEDOT-SS-PEG细胞化疗-热疗组合治疗54NR-PEDOT-SS-PEG血液循环及组织分布55NR-PEDOT-SS-PEG活体光热成像和磁共振成像57NR-PEDOT-SS-PEG活体化疗-热疗协同治疗583.4结论···················································································59第四章：纳米BSA装载有机上转换及聚集态荧光增强染料的制备与表征614.1前言·········