bmi1在nkt细胞淋巴瘤中的表达及其临床意义word格式论文.docxVIP

Methods: We selected 29 paraffin blocks with final diagnosispathologically NKTCL of of Guangzhou Medical College, Sun Yet-Sen University cancer center and Guangzhou First Municipal People’s hospital. Clinical data, including sex, age, clnical staging, LDH before treatment and so on are recorded. Bmi-1 expression was examined immunohistochemically. To analyze the relationship between prognosis and Bmi-1.Results: In 29 primary tumor tissues, 11（37.9%）patients showed Bmi-1 low expression，14（37.9%） patients showed Bmi-1 medium expression， while（13.8%） showed strong. There was no Bmi-1 expression in the adjacent tissues. The difference mentioned above shows significance when tested by chi-square test（P 0.05）. Also we found the Bmi-1 expression levels have no correlations with patients’ sex, age, LDH , primary site ,B symptoms, KPS scores, IPI scoresand Vascular Center of pathology（P0.05）, except for clinical stage（P 0.05）.The strong expression patients was more likely sharing an advanced stage. In survival analysis, the NKTCL patients who presented with Bmi-1 strong expression had longer OS after treatment. The median survival and the average survival in Low expression patients were 21.33 months and 29.94 months, while 31.67 months and 34.66 months separately in strong expression patients. Avnalysis byKaplan-Meier，the Bmi-1 and patients’ sex, age, LDH , primary site ,B symptoms, KPS scores,IPI scoresand Vascular Center of pathology expression levels have no correlations with patients’OS（P 0.05）（Bmi-1： P=0.859）。Conclusion：The Bmi-1 expression levels have correlations with patients’ clinical stage. The strong expression patients is more likely sharing an advanced stage. There is a trend that Bmi-1 strong expression patients have longer Overall Survival (OS).Key words: NKLCI；Bmi-1；Immunohistochemistry缩略语缩略词英文全名中文全名Bmi-1B—cell specific moloney murineleukemia virus integration site 1B 细胞特异的莫洛尼白血病毒插入位点 1 基因NKTCLExtranodal Natural Killer/T-celllymphomaNK/T 细胞淋巴瘤NHLNon－Hodgkin’s