有机化学（英文讲义）Chapter 8.pptVIP

Chapter 8 Elimination Reactions 8.1, 8.2 The general reaction General expression of elimination reactions (E reaction): 8.4 The stereoselectivity of E2 reactions 8.5 The regioselectivity of E2 reactions The regioselectivity of E2 reactions can be predicted as following rules: 1. Common E2 reactions follow Zaitsev’s rule: The olefin with more R groups on the carbons of the double bond is the major product. 2. Hofmann eliminations and E2 reactions with large base ( ) and the RX with a large steric hindrance for 2° -H follow Hofmann’s rule: The olefin with