基于磁共振弥散加权成像的唾液腺放射性损伤剂量—效应相关性研究-dose-effect correlation study of salivary gland radiation damage based on diffusion-weighted magnetic resonance imaging.docxVIP

基于磁共振弥散加权成像的唾液腺放射性损伤剂量-效应相关性研究目录摘要............................................................................................................................1ABSTRACT4第1 章前言..............................................................................................................9第2 章材料与方法................................................................................................112.1 临床资料与实验材料....................................................................................112.2 方法...............................................................................................................11第3 章结果............................................................................................................143.1鼻咽癌患者放疗前后腮腺及下颌下腺的表观扩散系数变化错误!未定义书签。99m3.2 鼻咽癌患者腮腺及下颌下腺放疗前后的最大酸反应泌（TcO4-）率（Ex）变化及与ADC值的相关性173.3 鼻咽癌患者临床口干表现...........................................................................193.4 鼻咽癌患者腮腺及下颌下腺剂量-体积关系（DVH）与腮腺及下颌下腺功能的相关性..............................................................................................19第4 章讨论............................................................................................................234.1鼻咽癌患者放疗前后腮腺及下颌下腺磁共振DW序列（DW-MRI）表观扩散系数（ADC值）的变化及意义234.2腮腺及下颌下腺放疗前后的最大酸反应泌（99MTCO4-）率（EX）变化与ADC值的相关关系264.3临床口干表现................................................................................................274.4 腮腺及下颌下腺剂量体积关系(DVH)图与腮腺功能的相关关系28结论........................................................................................................................32参考文献..................................................................................................................33致谢........................................................................................................................39综述..........................................................................................................................40- 2 -中文摘要目的：采用磁共振弥散加权成像（diffusion-weightedmagneticresonance imaging，DW-MRI）技术研究鼻咽癌患者在调强放射