基于代谢组学和糖组学技术的结直肠癌分析-analysis of colorectal cancer based on metabolomics and glycomics.docx

附件四上海交通大学学位论文原创性声明本人郑重声明:所呈交的学位论文，是本人在导师的指导下，独立进行研究工作所取得的成果。除文中已经注明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究做出重要贡献的个人和集体，均己在文中以明确方式标明。本人完全意识到本声明的法律结果由本人承担。学位时者签名:许础刹日期:1心1马年i月儿日万方数据附件五上海交通大学学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，同意学校保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权上海交通大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密口，在一一年解密后适用本授权书。本学位论文属于，不保密回(请在以上方框内打.J)学位论文作者签名:高斌叫日期:20{千年d月冯日上海交通大学博士学位论文答辩决议书所在0104159010姓名谭斌斌ι二且子口王0104159010学科答辩答辩生物学指导教师张延2014-06-26日期地点系统生物医学研究院B206会议室论文题目基于代谢组学和糖组学技术的结直肠癌研究投票表决结果:左/J?【(同意票数/实到委员数/应到委员数)答辩结论:tci4过口未通过评语和决议:谭斌斌同学的博士学位论文《基于代谢组学和糖组学技术的结直肠癌研究》选题新颖，符合转化医学研究领域的前沿研究方向，具有潜在的临床应用前景。该论文运用代谢组学和糖组学技术平台对结直肠癌开展了研究，筛选出与结直肠癌密切相关的血清代谢性候选标志物，并对其所蕴含的生化意义和潜在的临床应用价值进行了深入挖掘和探讨，为建立结直肠癌诊断模型奠定了基础。该论文还发展了一套有效筛选结直肠癌组织样本相关糖链生物标志、物的方法，显示了该方法的技术可行性，具有潜在的应用价值。该论文设计严密、方法可行、数据可信、分析有据、结论合理，结果有创新性。论文撰写规范、逻辑性强，表明了该生具有扎实的基础理论和专业知识，具备独立开展科研工作的能力。论文达到博士要求，建议推荐优秀博士学位论文。该生答辩思路清11析，回答问题准确。经答辩委员会无记名投票表决，一致同意通过该生警、的论文答辩，并建议授予理学博士学位。写:v但生=17]/1飞年6月，日职务姓名职称单位签名辩主席贾伟教授夏威夷大学1口?贝E刁委委员黄蔚研究员中科院上海药物研究所二F传主立三委员徐岩教授江南大学成(飞珍委员梁鑫森教授中科院大庄化学物理研究版贝名结A丘-委员陶生策研究员上海交通大学系统生物医学研究院11现j艺筝._，秘书杨芳(25044) 未评职称(实验人员〉上海交通大学私炜、目录专业词汇缩写表··········································································································· I摘要·························································································································IABSTRACT ··············································································································· V第一章前言················································································································11.1课题背景介绍······································································································11.1.1结直肠癌介绍·································································································································11.1.2代谢组学介绍····················································································································