基于点击化学改性生物降解聚乳酸的分析-analysis of biodegradable polylactic acid modified by click chemistry.docxVIP

优秀毕业论文 精品参考文献资料 Abstract Polylactic acid (PLA) for its biodegradable, good mechanical properties and processing properties and biocompatibility, is currently one of the most widely used materials of biomedical research and Medical Polymer fields. But there is a certain lack of Polylactic Acid Materials, the material is hydrophobic, lack of functional groups that can interact with Molecules and Cells, proteins, the cytocompatibility is not ideal as well. Therefore, it is necessary to make certain biological modification, to improve compatibility between their cells. Click chemistry is a chemical synthesis method proposed in recent years, with the advantages of highly selective, efficient, mild reaction conditions. In the modification of biological materials it has been increasingly applied, but also put forward new ideas for the modification of poly-lactic acid. To this end, the first part, alkynyl terminated poly(L-lactide) was synthesized by the bulk ring-opening polymerization of L-lactide under single-mode focus microwave radiation using stannous octoate (Sn(Oct)2) as a catalyst and propargyl alcohol as a co-initiator. The optimal synthesis conditions obtained by an orthogonal experiment were as follows: temperature of 110 ℃, microwave power of 45 W, irradiation time of 45 min and catalyst concentration of 0.1 % (mol%). Furthermore, a series of alkynyl terminated poly(L-lactide) have been synthesized rapidly and efficiently by changing npropargyl alcohol/nL-lactide feed ratio. The structure and properties of the product were studied by IR, 1H NMR, XRD, DSC and GPC. Results showed that the structure and properties of the alkynyl terminated poly(L-lactide) can be controlled by changing the npropargyl alcohol/nL-lactide feed ratio, with the L-lactide content increased, the molecular weight and melting point increased. In view of the water-solubility, excellent biocompatibility of chitosan oligosaccharide (COS) which has good osteogenic activity and is easily absorb