几种血液指标在炎症性肠病初步诊断及活动度评价中作用-the function of several blood indicators in that preliminary diagnosis and activity evaluation of inflammatory bowel disease.docxVIP

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几种血液指标在炎症性肠病初步诊断及活动度评价中作用-the function of several blood indicators in that preliminary diagnosis and activity evaluation of inflammatory bowel disease.docx

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几种血液指标在炎症性肠病初步诊断及活动度评价中作用-the function of several blood indicators in that preliminary diagnosis and activity evaluation of inflammatory bowel disease

TheRoleofSelectedBloodParametersinInitialDiagnosisandActivityAssessmentofInflammatoryboweldiseaseAbstractObjective:Toinvestigatewhetherthereweresignificantdifferencesinthedistributionofseveralselectedbloodparameters,includinghemoglobin(HGB),meancorpuscularvolume(MCV),plateletcount(PLT),redcelldistributionwidth(RDW),erythrocytesedimentationrate(ESR),C-reactiveprotein(CRP)andmeanplateletvolume(MPV)betweeninflammatoryboweldisease(IBD)andhealthycontrolgroups,orbetweenCrohnsdisease(CD)andUlcerativeColitis(UC)groups,oractiveandinactiveIBDgroups.Toevaluatetheroleoftheseparametersintheinitialdiagnosis,subtypediscriminationandactivityassessmentofIBD.ToassesstheroleofRDWintheactivityassessmentofIBDbyconductingadiagnosticmeta-analysis.Methods：OnehundredthirtyIBDpatients(including60CDand70UC)whowereresidinginSuzhou,aged18to65yearsandhadnofamilyhistoryofIBDwereenrolled.AllpatientshospitalizedinDepartmentofGastroenterologyofSuzhouMunicipalHospital(NorthCampus)betweenJune2008andJune2012,andwereconfirmedtohavebeensufferingfromIBDaccordingtocomprehensivediagnosis.Thepatientswerematchedto130healthycontrolswhowerefreeofIBDandothergastrointestinaldiseasesbyageandsex.HospitalizationdataforpatientsandthedataofbloodtestforbothIBDandcontrolswerecollected.TheactivityofthediseasewasassessedusingtheCrohnsdiseaseactivityindex(CDAI)forCDpatientsandthecorrectedTruelove-WittsindexforUCpatients,respectively.ActivediseasewasdefinedasaCDASofatleast150forCDanda英文摘要几种血液指标在炎症性肠病初步诊断及活动度评价中的作用correctedTruelove-Wittsindexofatleast11.ThemeanormedianlevelsoftheparametersbetweenIBDandcontrols,CDandUC,activeandinactiveCD,activeandinactiveUCwererespectivelyevaluatedtodetectwhetherthereweresignificantdifferencesinthelevelsoftheseparametersbetweengroups.Receiveroperatingcurve(ROC)analysiswasusedtodeterminetheareaunderthecurve(AUC),sensitivityandspecificityoftheseparametersindistinguishingIBDandcontrols,CDandUC,andactiveandinactiveIBD.AcomprehensiveliteraturesearchwasconductedbyuseofmultipledatabasescoveringMedl