TC方案和PAC方案用于上皮性卵巢癌术后化疗比较.docVIP

TC方案和PAC方案用于上皮性卵巢癌术后化疗比较 【关键词】TC方案 P style=TEXT-INDENT: 24px align=left【摘要】 目的 观察比较TC和PAC方案治疗上皮性卵巢癌的不良反应及近期疗效。方法 对1999年1月～2002年1月收治的52例上皮性卵巢癌患者进行回顾性分析，26例患者手术加TC方案化疗，26例患者手术加PAC方案化疗，观察化疗后不良反应和近期疗效。结果 TC组完成1～3个疗程的有效率为38.5%，完成4～6个疗程的有效率为66.7%;PAC组完成1～3个疗程的有效率为23%，完成4～6个疗程的有效率为63.6%;两组的不良反应为骨髓抑制、恶心呕吐，末梢神经毒性、肾功能损害、脱发等，两组方案在胃肠道反应、周围神经毒性和发热方面存在统计学差异，其它毒性两组都存在，但TC方案较PAC方案轻。结论 TC方案及PAC方案在治疗上皮性卵巢癌中均有较好疗效;TC方案的毒性反应较PAC方案轻，如患者经济状况允许可作为上皮性卵巢癌术后化疗的一线用药。P style=TEXT-INDENT: 24px关键词 上皮性卵巢癌 化学方法 TC方案 PAC方案P style=TEXT-INDENT: 24px align=centerComparison on TC and PAC chemotherapeutic regimes in postoperationP style=TEXT-INDENT: 24px align=centertreatment of epithelial ovarian cancerP style=TEXT-INDENT: 24px align=centerWang XiaoyanP style=TEXT-INDENT: 24px align=centerThe First Hospital of Laohekou，Hubei441800.P style=TEXT-INDENT: 24px【Abstract】 Objective To compare the short-term curative effects and the side effects between TC（Paclitaxˉel+Carboplatin）and PAC chemotherapeutic regimes in treating epithelial ovarian cancer after surgery.Methods A retrospective studywas performed on52patients with epithelial ovarian cancer who were hospitalized in Nanfang hospiˉtal between Jan.1999and Jan.2002.The patients were dividedinto2groups.In TC group26cases received operation plus TC regime，and in PAC group other26cases received operation plus PAC regime.The side effects and the curaˉtive effects of chemotherapy were obseved.Results The effective rate of patients receiving1～3courses of treatment in TC group was38.5%，and66.7%for the patients receiving4～6courses.While，the effective rate of patients reˉceiving1～3courses of treatment in PAC group was23%，and63.6%for the patients receiving4～6courses.Side effects including bone marrow depression，nausea，emesis，peripheralneurotoxicity，renal function impairment，loss of hair，and so on，were all found in both groups.However，statistical difference was found in gastrointestinal response，peˉripheral neurotoxicity or drug-caused fever between the2groups，andth