多重人乳头瘤病毒感染与宫颈癌及癌前病变的相关研究.docVIP

多重人乳头瘤病毒感染与宫颈癌及癌前病变的相关研究 作者：赵爱华,张红华 单位：广东省佛山市同济医院，广东 佛山 ；广东省佛山市妇幼保健院，广东 佛山 【摘要】 目的 探讨高危型人乳头瘤病毒（human papillomavirus,HPV）的感染与宫颈癌及癌前病变的关系。方法 对就诊的有宫颈疾患的妇女483例，采用HPV基因分型技术进行高危型DNA的检测，阴道镜下定位活检。病理学结果为确诊标准。结果 高危型HPV检测阳性180例，阳性率37.23%，各种病理类型的宫颈病变中高危型HPV感染率分别为：宫颈鳞癌13.89%，宫颈腺癌12.56%，CINIII 32.77%，CINII 56.3%，CINI 44.58%，宫颈扁平湿疣86.69%，慢性宫颈炎79.59%。单一型别感染率为38.89%多型感染中2种型别感染比例最多57.86%。从正常组织到宫颈上皮内瘤样病变（CIN）II的不同病变中，多重感染的比例随病变级别上升逐渐增加，与正常者相比差异有显著性意义（P＜0.05）。在CINIII和宫颈癌中，多重感染的比例有所下降，但明显高于正常者。HPV联合宫颈薄层液基细胞学（TCT）检测与单纯TCT检测比较，两者中低度鳞状上皮内病变（HSIL）为4.17%和0.78%，癌为0.56%和0.20%，两者差异有显著性意义，P＜0.01。结论 结合HPV检测可提高TCT检测的敏感性，多重HPV感染及型别与宫颈病变级别相关。 【关键词】 人乳头瘤病毒；宫颈上皮内瘤样变；宫颈癌；HPV基因分型 The research on the relevance of Multiple high-risk human papillomavirus infection and cervical cancer precancerous lesionsZHAO Ai-Hua ，ZHANG Hong-hua.　（Foshan City,Guangdong Province Tongji Hospital， Foshan，528000，china　［Abstract］ Objective To discuss the connection of high-risk human papilloma virus(human papillomavirus, HPV) infection and cervical cancer and precancerous lesions(CIN) .Methods 483 cases of woman with HPV was treated with HPV type of technology to high-risk HPV DNA test and colposcopy under biopsies .The pathological results confirmed standards.Results According to the high-risk HPV tests ,180 cases were positive and the positive rate was 37.23% .The percentages of various pathological types of cervical lesions in high-risk HPV infection are: cervical flat condyloma,CIN1II 32.77%,CINII56.30% , CINI 44.58%,cervical flat condyloma 86.69%,chronic cervical 79.59%. Single type infect was 38.89%, multi-infection rate in the infection of more than two kinds was 57.86%. From normal tissue to cervical intraepithelial neoplasia lesions (CIN II) of the different disease, the proportion of multi-infection with the disease-level rising gradually increased and difference was statistically significant, compared with the normal (P＜0.05). In the CIN III and cervical cancer, the percentage of multi-infection declined but was