妇康冲剂的雌激素样作用及对神经及免疫两系统的调节作用.docVIP

妇康冲剂的雌激素样作用及对神经及免疫两系统的调节作用 【关键词】妇康 P style=TEXT-INDENT: 24px【摘要】 目的 以系统的药效学实验验证妇康冲剂的功效。方法 采用T淋巴细胞增殖反应、腹腔巨噬细胞吞噬功能测试对免疫系统的调节作用;以小鼠自主活动和避暗法检测对中枢神经系统活力的影响;以成年去卵巢大鼠阴道角化细胞、子宫湿重及血清雌二醇含量的测定观察雌激素样作用;以肝脏及脑组织过氧化脂质含量的变化观察抗脂质过氧化作用。结果 研究表明该冲剂具有增进小鼠中枢神经系统活力，调节免疫功能，抗脂质过氧化并对去卵巢大鼠具有的雌激素样作用。结论 妇康冲剂可作为调节中老年妇女机体功能的保健用药。P style=TEXT-INDENT: 24px关键词妇康冲剂 免疫功能 过氧化脂质 雌激素P style=TEXT-INDENT: 24px align=centerThe estrogen-like activity and the effects of regulating immunologicP style=TEXT-INDENT: 24px align=centersystem and nervous system of fukang granule preparationP style=TEXT-INDENT: 24px align=centerZhao Xiaoping，Xia Zhijun，Lv Min，et al.P style=TEXT-INDENT: 24px align=centerDepartment of Laboratory Medicine，Zhejiang Medicine College，Hangzhou310053P style=TEXT-INDENT: 24px【Abstract】 Objective Systemic pharmacodynamics experiments were used to verify the functions of Fukang granules.Methods The immunoregulation is tested by the proliferate reaction of T lymphocyte and phagocytosis of celio-macrophage;the affect of C.N.S activity is examined by the mouse’s autonomic activity and the darkness-avoidance test;the estrogen-like function is observed by the vagina keratinized cell，uterus hygro-weight and the serum estradiol content of de-ovary adult mouse;the anti-lipid peroxidization is observed by the content change of the peroxidize lipid in liver and brain.Results The study showed the nerve-system functions could be strengthˉened，the immunologic functions could be regulated and the lipid peroxide could be reduced by the granules.In addiˉtion the granules have the estrogen-like function of de-ovary adult mouse.Conclusion The Fukang granules could be used as a medicine of regulating organism function of old and middle-aged women.P style=TEXT-INDENT: 24pxKey words fukang granules immuuologic function lipid peroxide estrogenP style=TEXT-INDENT: 24px老龄社会，中老年妇女机体状况逐渐衰退，种种表现如记忆力减退、免疫功能低下、卵巢功能减退等已严重影响到她们的工作和生活。为改善这一现状，我们对由鹿角片、红参、黄芪、龟板、原蚕蛾、枸杞子等中药制成的中医验方“妇康”冲剂进行了系统的药效学研究，证明该冲剂具有雌激素样作用，并能提高动物机体免疫力及调节中枢神经