妈富隆治疗耐氯米芬多囊卵巢综合征不孕的临床观察.docVIP

妈富隆治疗耐氯米芬多囊卵巢综合征不孕的临床观察 【摘要】目的观察妈富隆联合延长氯米芬（CC）服药时间或妈富隆联合低剂量FSH-HP开始促排卵方案治疗耐CC多囊卵巢综合征（PCOS）不孕的临床效果。方法选择耐CC的PCOS伴不孕的患者32例，73个治疗周期，随机分为2组。A组：妈富隆＋CC组，16例，38个周期；B组：妈富隆＋FSH-HP组，16例，35个周期。全部患者先用妈富隆治疗2个月并测定治疗前后血清性激素、卵巢体积和窦卵泡数。然后连续促排卵治疗3个周期，停药后比较A组和B组的周期排卵率、妊娠率、卵巢过度刺激综合征（OHSS）发生率和多胎率以及流产率。结果妈富隆治疗后血清LH、FSH、LH/FSH、T、E2、PRL水平，双侧卵巢体积、窦卵泡个数均较治疗前明显下降（P0.01）。A组和B组周期排卵率分别为81.6%和91.4%、周期妊娠率分别为31.6%和42.9%、周期OHSS发生率分别为7.9%和2.9%、流产率分别为16.7%和13.4%、多胎率分别为16.7%和6.7%，A组和B组各相应的率间比较，差异均无统计学意义（P0.05）。结论对耐CC的PCOS不孕患者，先行妈富隆前期治疗再用延长CC服药时间或低剂量FSH-HP开始促排卵治疗均能提高卵巢对促排卵的反应性，可以获得较高排卵率、妊娠率和较低OHSS、多胎妊娠的发生率，均是有效的促排卵方案。 【关键词】 妈富隆;氯米芬抵抗;多囊卵巢综合征 Clinical observation on the effect of mawelon on infertility in women with Clomiphene-resistant polycystic ovary syndrome. SUN Jing, QI Guo-hua, XIONG Xiao-ying, et al. （Shekou Peoplersquo;s Hospital of Shenzhen, Shenzhen 518067, Guangdong, P. R. China） Abstract：Objective To observe the clinical effects of marvelon combined with extended clomiphene citrate （CC） or marvelon combined with low dosage FSH-HP （metrodin-HP） on infertile women with clomiphene-resistant to polycystic ovary syndrome （PCOS）. Methods There 32 infertile women with CC-resistant to PCOS were randomly divided into group A consisted of 16 cases and treated with marvelon plus CC for 38 cycles Group B consisted of 16 cases and treated with marvelon plus FSH-HP aldo for 35 cycles. Before given ovulation induction drugs, all women were treated with marvelon for 2 months and the level of sexual hormone, ovary size and the ovary antral follicle counts before and after therapy were determined. Ovulation was induced after 3 induction cycles, the rates of ovulation per cycle, pregnancy per cycle, OHSS occurrence per cycle, multipregnancy and abortion were determined and analysed. Results The levels of serum LH, LH/FSH, T,E2, PRL, bilateral overy sizes and antral follicle counts were significantly increased （P0.01）. The ovulation rates,pregnancy rates, OHSS occurrence rates per cycle, abortion rates and mult