妊娠与分娩对首发精神分裂症患者病情复发的影响.docVIP

妊娠与分娩对首发精神分裂症患者病情复发的影响 【摘要】目的 探讨妊娠与分娩对首发精神分裂症患者病情复发的影响。方法对219例育龄女性首发精神分裂症患者进行了为期3年的随访，将完成随访的186例患者按患病后有无妊娠及分娩分为妊娠及分娩组（下称妊产组，121例）和未妊娠组（下称非妊产组，65例），将两组的相关资料进行比较。结果 妊产组复发率（79.3%）、平均发病次数(3.7±2.1)及住院次数(1.8±1.2)显著高于非妊产组(63.1%、1.8±1.3、0.9±0.6；P0.05,P0.01)；家庭和社会支持、服药依从性及维持应用抗精神病药剂量均显著差于非妊产组（均P0.01）。在妊产组中，病情稳定组孕后维持治疗及家庭和社会支持率显著高于妊娠期复发组和产后复发组（均P0.01）。结论 妊娠及分娩与首发精神分裂症患者病情复发有关，但是否为复发的直接因素尚需进一步探讨。 【关键词】 精神分裂症，首发；妊娠；分娩；疾病复发 Influence of Pregnancy and Parturition on Patients with First Episode of Schizophrenia∥ZHAN Laiying， LIU Lin， FU Fengzhen， et al∥(Jining Hospital for Prevention and Treatment of Psychiatric Diseases, Jining 272051， China) Abstract： Objective The aim of this study was to explore the influence of pregnancy and parturition on women with schizophrenia. Methods Two hundred and nineteen women with the first episode of schizophrenia were followed up for three years and 186 cases of them were analyzed. They were divided into pregnancyparturition group (n=121) and nonpregnancyparturition group (n=65). Clinical data of the groups were compared with the other group and statistically analyzed. Results There were 96 cases (79.3%) of recurrence in 121 cases of pregnancyparturition group. The attack frequency (79.3%, 96/121), average times of episodes (3.7±2.1) and times of hospitalization (1.8±2.1) in pregnancyparturition group were higher than in nonpregnancyparturition group (63.1%,41/65;1.8±1.3;0.9±0.6)(P0.05, P0.01). The measures in family and social support, medicine compliance and dosage of antipsychotic drugs for maintenance treatment in pregnancyparturition group were poorer than in nonpregnancyparturition group (P0.01). The dose of antipsychotic drug in pregnancyparturition group were lower than in nonpregnancyparturition group (P0.01). The pregnant woman with stable condition had higher rates of maintenance treatment and social and family support as compared with women with recurrences during or after delivery(P0.01). Conclusion Pregnancy and partu