瞬时受体电位通道_高血压相关治疗的新靶点.pptVIP

瞬时受体电位通道 ---高血压治疗的新靶点 Transient Receptor Potential Channels A novel target for treatment of Hypertension 祝之明;;高血压的非药物干预;高血压的药物治疗;高血压的药物治疗 (Drugs related to RAAS);Lifton RP, Cell, 2001 O’Shanghnessy KM, JCI, 2004;Cosens, D. J. Manning, A. Abnormal electroretinogram from a Drosophila mutant. Nature 224, 285-287 (1969); 一种新的非选择性阳离子通道家族，体内分布广泛，分不同的亚型;瞬时受体电位通道 Transient receptor potential channels (TRPCs);Distribution of TRP channels in vasculature; Possible function of TRPCs in the vasculature;TRP通道与疾病的联系;TRPC6 in hypertension;Role of TRPV1 in hypertension;Role of TRPM7 in hypertension;高血压病人和SHR单核细胞TRPC3表达上调，其介导的钙内流增加;Role of TRPC3 in the pathogenesis of hypertension;Identification of TRPC3 in the vasculature ;Increased expression of TRPC3 in aorta from SHR ;Effect of TRPC3 upregulation on angiotensin II -induced calcium increase in SHR;Effect of TRPC3 gene knockdown on angiotensin II induced calcium increase in SHR;Angiotensin II increases TRPC3 in VSMC from SHR;Effect of CCB/SKF on Angiotensin II-induced aortic contraction and calcium increase in VSMC from SHR;Long term administration of AT1R antagonist telmisartan but not of calcium channel blocker amlodipine reduces TRPC3 in vivo;Vasomotion occurs in arteries either spontaneously or in response to pressure, stretch or application of vasoconstrictor agonists, which is associated with slow oscillations of smooth muscle membrane potential and of intracellular calcium concentrations. Vasomotion may also be enhanced by oscillations of transplasmamembrane calcium influx. TRP channels have been described to play an important role for calcium influx. ;What is pathophysiological relevance of vasomotion ? ;Norepinephrine (NE) caused a rapid vasonconstriction and followed by synchronized oscillations of vascular tone (vasomotion) in mesenteric artery rings from SHR ;Increased NE-induced vasomotion in mesenteric artery rings from SHR;Immunohistochemistry shows TRPCs distribution in mesenteric arteries;Incr