急性脊髓损伤大鼠mir-223对中性粒细胞介导炎症反应相关性分析-correlation analysis of mir - 223 on neutrophil-mediated inflammatory response in rats with acute spinal cord injury.docxVIP

低，可以减轻中性粒细胞介导的炎症反应。【关键词】:急性脊髓损伤、miR-223、IL-6、IGF1-R、炎症、继发性损伤AcutespinalcordinjuryinratsofmiR-223neutrophilsmediatedinflammatoryresponsecorrelationstudies【Abstract】ThepurposeofthisstudywastodetecttheacutespinalcordinjuryinratsinthechangesofinflammatoryfactorsandmiR-223expression,andexpressionofmiR-223anditsdownstreamgeneIGF1-R,analysisofmiR-223andneutrophilsmediatedinflammatoryreactionsinspinalcordsecondaryinjuryprocess,andtodiscussthepossibilityasarelievesecondaryspinalcordinjury.【Methods】ThemodifiedAllen,establishesamodelofacutespinalcordinjuryinrats.The198ratswererandomlydividedintogroupswit