电针头穴加灸法治疗汶川“5.12”地震后创伤后应激障碍的临床rct研究论文论文.docVIP

成都中医药大学硕士学位论文 中文摘要 　 目的：研究电针头穴加灸法治疗 ５．１２ 地震后创伤后应激障碍（ＰＴＳＤ）的临 床疗效，为电针头穴加灸法治疗 ＰＴＳＤ 提供可靠证据。　 方法：采用随机对照试验的方法，将纳入试验的 １３８ 例患者随机分配到电 针头穴加灸法组和西药帕罗西汀组，共治疗 １２ 周。于治疗前，治疗 ６ 周后，治 疗 １２ 周后，对 ＰＴＳＤ 临床监测量表（ＣＡＰＳ）、汉密尔顿抑郁量表（ＨＡＭＤ）、汉密 尔顿焦虑量表（ＨＡＭＡ）三个量表进行评分，对疗效进行评价。治疗副反应量表 （ＴＥＳＳ），于治疗前，治疗期间前四周每周一次，治疗五周至十二周每两周进行 一次评定，评价药物副反应。　 结果：该试验完成情况良好，两个组分组均衡，基线状况良好，可比性强。 通过对 ＣＡＰＳ 量表、ＨＡＭＤ 量表和 ＨＡＭＡ 量表积分的分析发现，治疗前后评分组内 比较均有显著性差异（Ｐ＜０．０１），组间比较没有统计学意义（Ｐ＞０．０５）。通过对 ＣＡＰＳ 量表、ＨＡＭＤ 量表和 ＨＡＭＡ 量表积分的减分率的分析发现，不同时间段内减 分率组内比较均有显著性差异（Ｐ＜０．０１），组间比较只有 ＨＡＭＡ 量表积分的减分 率具有统计学意义（Ｐ＜０．０５），ＣＡＰＳ 量表和 ＨＡＭＤ 量表积分的减分率的组间差异 无统计学意义（Ｐ＞０．０５）。　 结论：电针头穴加灸法治疗 ＰＴＳＤ 的总体疗效与西药帕罗西汀相当，但在对 焦虑症状的改善方面优于西药帕罗西汀，且该方法安全性高，值得推广。　 关键词：ＰＴＳＤ　　电针　　灸法　　ＲＣＴ　　 　 　 　 　 3 成都中医药大学硕士学位论文 Abstract Objective: To study the therapeutic effects of scalp electric acupuncture combining with moxibustion in treating posttraumatic stress disorder(PTSD) after Wenchuan 5.12 earthquake.And to provide the solid evidence to clinical applications of acupuncture and a new method to prevent PTSD. Methods:A total of 138 patients were recruited in this trial and randomly divided into two groups through RCT: paroxetine hydrochloride group (control group) and scalp electric acupuncture with moxibustion group (treatment group). Each group was treated for 12 weeks. Patients were scored relatively before the treatment, six weeks after the treatment, and twelve weeks after the treatment, using Clinician-administered Scale for DSM-IV (CAPS), Hamilton Depression Rating Scale for Depression (HAMD), and Hamilton Anxiety Scale (HAMA). Treatment Emergent Symptom Scale (TESS) is used to analyze the side effects of the drug every week in the first four weeks and every two weeks in the rest weeks. Results:The research was finished well, with a balanced grouping, a stable baseline, and a significant comparability. After the analysis of integrations of CAPS, HAMD, and HAMA, we found that the score differences before and after the treatment were of statistical significance in all four groups (P0.01), but of no