hbv感染不同免疫状态与pⅲp np cⅳ表达水平的分析-analysis of different immune states of hbv infection and expression level of p ⅲ p np c ⅳ.docx

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hbv感染不同免疫状态与pⅲp np cⅳ表达水平的分析-analysis of different immune states of hbv infection and expression level of p ⅲ p np c ⅳ.docx

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hbv感染不同免疫状态与pⅲp np cⅳ表达水平的分析-analysis of different immune states of hbv infection and expression level of p ⅲ p np c ⅳ

Study on the expression of PⅢP N-P and C-Ⅳ inpatients with HBV infection during different immune statusABSTRACTObjective: To study the expression and significance of the serum levels ofPⅢP N-P and C-Ⅳ in patients with HBV infection during different immune status.Methods : Grouping the patients of HBV infection into three teams with immune tolerance, immune clearance, immunodeficiency. Serum samples were collected from 20 cases of immune tolerance, 20 cases of immune clearance, 20 cases of Immuno deficiency and 20 cases of normal control. Serum levels ofPⅢP N-P and C-Ⅳ were measured by the electrochemical luminescence method.Results: the serum levels of PⅢP N-P show:the immune clearance and immunodeficiency group were higher than the normal control group and significant difference were found between them(z=-5.041,-4.095,P0.05). Theserum expression level of PⅢP N-P had no significant difference betweenimmune tolerance group and normal control group (z=-1.6504, P0.05).And the serum expression level of PⅢP N-P of immune clearance group andimmunodeficiency group were higher than immune tolerance group respectively (z=-5.356, -4.599, P 0.05).No significant difference was found between immune clearance group and immunodeficiency group (z=-1.136, P0.05). theserum levels of C-Ⅳ show: Immune clearance group and immunodeficiencygroup had significant difference with normal control group respectively(z=-3.273, -4.166, P 0.05).But no significant difference was found betweenimmune tolerance group and normal control group (z=-0.514, P 0.05). The serum expression level of C-Ⅳ in immune clearance and immunodeficiencywere higher than that in immune tolerance group respectively (z=-2.570, -2.732, P 0.05). No significant difference is found between immune clearance group and immunodeficiency group (z=-0.514, P 0.05). Conclusions: Serum levelsof PⅢP N-P, C-Ⅳ are closely related with the immune status in patients withchronic HBV infection. The expression levels of PⅢP N-P, C-Ⅳ have i