Diabetes糖尿病英文.pptVIP

04? Pathogenesis 4.1 The Pathogenesis of Type 1 Is related to genetic factors, environmental factors and autoimmunity 1）genetic predisposition 2）start autoimmune response 3）immumological abnormalities 4）progressive loss of islet B cell function 5) clinical diabetes 6）islet B cells destroyed,diabetes clinical manifestations 04? Pathogenesis 4.2 The Pathogenesis of Type 2 Its occurrence and development can be divided into four stages 1 ）Genetic susceptibility 2） Hyperinsulinism, and/or insulin resistance 3 ）Glucotoxicity(糖尿病毒性),lipotoxicity(脂毒性) 4 ）Clinical diabetes * immune 免疫 autoimmunity 自身免疫 immumological 免疫学的 hyper- 高 Hyperinsulinism 高胰岛素症 Hyperglycemia 高血糖 toxic 毒的，中毒的，有毒的 Glucotoxicity 糖尿病毒性 lipotoxicity 脂毒性 Word Analysis 05? Clinical Manifestations 5.1 Type 1 Diabetes Mellitus Polyuria Polydipsia Polyphagia Weight loss 05? Clinical Manifestations 5.2 Type 2 Diabetes Mellitus Non-specific symptoms Fatigue Recurrent infections Prolonged wound healing Visual changes * proteolysis蛋白质水解 lipolysis脂类分解 arthrolysis关节松解术 -lysis松解术，分解，溶解 prote-蛋白质 lipo-脂肪的 arthro-关节 Word Analysis 06? Complications 6.1 Diabetic Ketoacidosis(DKA) It is the most common acute complication of diabetes mellitus. The early manifestations of DKA is that the symptoms being more serve ,such as polydipsia、polyuria、polyphagia and so on.The DKA is characterized by different degrees of disturbance consciousness in the advanced stage. 06? Complications 6.2 Hyperglycemic hyperosmolar status (HHS) Main clinical features: hyperglycemia crisis(高血糖危象),higher plasma osmotic pressure(高血浆渗透压),dehydration(脱水). Minor clinical manifestation: varying degrees of disturbance consciousness or coma ,unconspicuous DKA. 06? Complications 6.3 Infectious complications Pyogenic inflammation : furuncle,carbuncle,pustule,etc. Fungal infection: tinea pedis ,tinea corporis,etc. Pulmonary tuberculosis Figure2： Infectious complications 06? Co