结核分枝杆菌tgs1蛋白的生理效应及调控机制初探-preliminary study on physiological effects and regulatory mechanism of mycobacterium tuberculosis tg s1 protein.docx

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2018-05-29 发布于上海
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结核分枝杆菌tgs1蛋白的生理效应及调控机制初探-preliminary study on physiological effects and regulatory mechanism of mycobacterium tuberculosis tg s1 protein.docx

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结核分枝杆菌tgs1蛋白的生理效应及调控机制初探-preliminary study on physiological effects and regulatory mechanism of mycobacterium tuberculosis tg s1 protein

ExploringPhysiologicalEffectandRegulationMechanismofTgs1ProteininMycobacteriumTuberculosisAbstractTuberculosis(TB),causedbyMycobacteriumtuberculosis,continuestobeamajorculpritofmorbidityandmortalitythroughouttheword.Aboutonethirdoftheworld’spopulationis,orhasbeeninfectedwithMycobacteriumtuberculosis.Recentyears,theemergenceofHIVanddrug-resistantTBaggravatedtuberculosissituation.Drug-resistantandmulti-drugresistantmycobacteriumtuberculosisoutbreakhasbecomeaseriouspublichealthproblemworldwide.In1998,SangercentreinBritainandFrancePaseteurinstitutescientistsincollaborationwiththeMycobacteriumtuberculosisH37Rvstrainofgenesequencing.In2001,thescientistsinUnitedStatesNewYorkisolatetheCDC1551whichhasnotoxicandsequencedgenesequence.Afterthat,moreclinicalMycobacteriumtuberculosisstrainshasbeenisolated,includingextremedrug-resistantstrainsofmultidrug-resistantstrains,wholegenomesequencesarereleasedintothedatabase.AftertheMycobacteriumtuberculosisgenomesequencingandgenomeresearch,itcanhelphumantorealizetheintegrityofmicrobialbiologyfunctionandhelptoMycobacteriumtuberculosismorphology,structure,metabolicpathway,pathogenesisanddrugresistancemechanismresearch,specificdiagnosticreagentsforresearchandprotectivevaccineandeffectivedrugsprovideascientificbasis.AndtheproteomicstechnologyappliedintheresearchfieldofMycobacteriumtuberculosis,toelucidatethepathogenesisoftuberculosis,preparationanddesignsanewvaccine,realizestheeffectivepreventionandtreatment,hasimportantvalue.MycobacteriumtuberculosisdosRsystemmaybeassociatedwiththelatentmycobacteriumtuberculosis.InMycobacteriumtuberculosis’sgenome,Tgs1positionisnearRv3133candRv3132cwhichcodeddosRanddosS.AlotofM.tuberculosistranscriptionalexperimentalshowsthattheycanbeusedasageneclusteroftranscription.It’sworthnothingthattherearemanygeneswhichcodePE/PPEproteinfamilyindownstreamofgene-cluster.Thereis5%proteininM.tuberculosisbelongstoPE/PPEproteinfamily.ThisproteinfamilyisnecessarytogiveplaytothevirulenceandpersistentinfectionofM.tuberculosis.