抗菌药物专项整治对细菌耐药的影响及pct crp在下呼吸道感染中的临床意义-the influence of special antimicrobial treatment on bacterial drug resistance and the clinical significance of pct crp in lower respiratory tract infection.docx

PAGE PAGE IV 抗菌药物专项整治对细菌耐药的影响及 PCT、CRP 在下呼吸道感染中的临床意义 英文摘要 The effect of the antibiotics management on the bacterial resistance and the role of procalcitonin and C-reactive protein in the lower respiratory tract infections Abstract Objective: To evaluate the effect of the antibiotic control and management on bacterial resistance and explore the role of procalcitonin (PCT) and C-reactive protein (CRP) in lower respiratory tract bacterial infections, which could be helpful for the proper use of antibiotics. Methods: The data of antibiotic use, the biological assay rate, the gram negative (G-) and gram positive (G+) bacterium resistance in Lianyungang First People’s Hospital in the year 2010, 2011 and 2012 were retrospectively analyzed. According to the clinical manifestations, radiology and bacterial cultures, 135 cases hospitalized in Lianyungang First People’s Hospital were diagnosed to be lower respiratory tract bacterial infections (37 with G+ and 98 with G- bacterial infections). 31 healthy persons were the control. The data of PCT, CRPin both groups were analyzed. The differences of PCT, CRP, white blood cells（WBC）, neutrophils (N) and lymphocytes (L) between the G- and G+ groups were analyzed. The relationship between the PCT and CRP were calculated. Results: The clinical data of antibiotic use in Lianyungang First People’s Hospital decreased year by year after the antibiotic control and management. Compared the antibiotic use in in-hospital patients and out-hospital patients in 2010, that in 2012 significantly reduced (P0.05). The clindamycin, moxicillin, linezolid and vancocin resistant G+ bacterium reduced from 2010 to 2012, and that in 2012 was greatly lower compared to that in 2010 (P0.05). The piperacillin/tazobactama, ceftazidime, aztreonam and imipenem resistant G- bacterium reduced from 2010 to 2012, and that in 2012 was greatly lower compared to that in 2010 (P0.05). However, the levofloxacin, cepoperazon and amikacin resistant G- 英文摘要