雷公藤红素对人胆管癌tfk-tripterine for tfk in human cholangiocarcinoma.docxVIP

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雷公藤红素对人胆管癌tfk-tripterine for tfk in human cholangiocarcinoma.docx

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雷公藤红素对人胆管癌tfk-tripterine for tfk in human cholangiocarcinoma

目录英文缩略词表·················································································2前言···························································································4中文摘要························································································7ABSTRACT10第一部分雷公藤红素对胆管癌细胞增殖和细胞周期的影响··········14材料与方法······································································14结果············································································19讨论············································································22第二部分雷公藤红素对胆管癌细胞凋亡及其相关蛋白表达的影响25材料与方法······································································25结果············································································30讨论············································································32第三部分雷公藤红素对胆管癌荷瘤鼠抗肿瘤作用及机制初探·······36材料与方法······································································36结果············································································40讨论············································································44全文总结·······················································································50综述雷公藤红素的抗炎及抗肿瘤作用分子靶向研究进展··········51参考文献·······················································································69附录1攻读学位期间发表论文··················································91附录2攻读学位期间参加的学术会议········································92致谢··························································································93英文缩略词表英文缩写英文全称中文全称CCAHCCCholangiocarcinomaHepatocellularcarcinoma胆管细胞型肝癌/胆管癌肝细胞型肝癌/肝癌PSCPrimarysclerosingcholangitis原发性硬化性胆管炎PDTPhotodynamictherapy光动力疗法WHOWorldHealthOrganization世界卫生组织FDAFoodandDrugAdministration美国食品和药物管理局TCMTraditionalChineseMedicine中国传统医学/中医CAMComplementaryandalternativemedicine补充和替代医学SLNSolidlipidnanoparticles固体脂质纳米粒FCMFlowcytometer流式细胞仪PIPropidiumiodide碘化丙啶DMSODimethylsulfoxide二甲基亚砜PBSPhosphatebufferedsaline磷酸盐缓冲液ODOpticaldensity光密度值XIA