利福平对鱼藤酮诱导的神经细胞sh-rifampin on rotenone-induced nerve cell sh.docxVIP

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利福平对鱼藤酮诱导的神经细胞sh-rifampin on rotenone-induced nerve cell sh.docx

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利福平对鱼藤酮诱导的神经细胞sh-rifampin on rotenone-induced nerve cell sh

目录中文摘要·································································································1ABSTRACT3前言······································································································5第一部分鱼藤酮诱导的神经细胞SH-SY5Y凋亡模型的建立····························7材料与方法···························································································7结果································································································13讨论································································································17参考文献····························································································18第二部分利福平对鱼藤酮诱导的神经细胞SH-SY5Y凋亡的抑制作用··············19材料和方法·························································································19结果································································································25讨论································································································28参考文献····························································································30第三部分利福平对鱼藤酮诱导的神经细胞SH-SY5Y凋亡抑制作用的内在机制····31材料和方法·························································································31结果································································································38讨论································································································40参考文献····························································································41综述··································································································42附录··································································································49致谢··································································································50利福平对鱼藤酮诱导的神经细胞SH-SY5Y凋亡的抑制作用硕士研究生：徐鋆阳导师姓名：王涛教授中文摘要帕金森病(Parkinson’sdisease,PD)是一种常见的神经退行性疾病，黑质多巴胺能神经元选择性地死亡、丢失导致多巴胺水平下降是其主要病因。因此关于PD的治疗，对神经元的保护是目前研