临床因素涎腺粘液表皮样癌预后的影响一项回顾性研究-clinical factors influencing the prognosis of mucoepidermoid carcinoma of salivary gland a retrospective study.docxVIP
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临床因素涎腺粘液表皮样癌预后的影响一项回顾性研究-clinical factors influencing the prognosis of mucoepidermoid carcinoma of salivary gland a retrospective study
SIGNATURESOFSUPERVISOR(S)Principalresearcher………………………………………………………………….Signature…………………………………………Date………………………………Supervisor……………………………………………………………………………..Signature………………………………………....Date………………………………...Supervisor………………………………………………………………………………Signature………………………………………….Date………………………………COPYRIGHTI,……………………………………………………………………………………………………………doherebydeclarethatthethesisofmyresearchisacopyrightofTongjiMedicalCollegeofHuazhongUniversityofScienceandTechnology,Wuhan,China.ABBREVIATIONSMEC:MucoepidermoidcarcinomaOS:OverallsurvivalDFS:DiseasefreesurvivalLG:LowgradeIG:IntermediategradeHG:HighgradeMSG:MajorsalivaryglandMISG:MinorsalivaryglandSMG:SubmandibularglandSLG:SublingualglandSx:SurgeryRT:RadiotherapyLN:LymphnodeLISTOFCONTENTSLISTOFTABLESANDFIGURESTable1:CharacteristicofpatientwithMEC10Table2:Demographicdetails12Table3:Relationshipbetweentumorgradeandtreatmentmodalities15Table4:Resultsofunivariateanalysis19Figure1:Kaplan-Meiergraphforoverallsurvivalanddiseasefreesurvival16Figure2:Kaplan-Meiergraphofoverallsurvivalforagegroup28Figure3:Kaplan-Meiergraphofdiseasefreesurvivalforagegroup28Figure4:Kaplan-Meiergraphofoverallsurvivalforgender29Figure5:Kaplan-MeiergraphofoverallsurvivalforTstatus29Figure6:Kaplan–MeiergraphofoverallsurvivalforNstatus30Figure7:Kaplan–Meiergraphofoverallsurvivalforclinicalstage30Figure8:Kaplan–Meiergraphofoverallsurvivalforhistologicgrade31Figure9:Kaplan–Meiergraphofdiseasefreesurvivalgraphforhistologicgrade.31Figure10:SuggestedhistogenesisofMEC……………………………………..47摘要背景:粘液表皮样癌是发生在大小涎腺的最常见的恶性肿瘤,我们研究的目的是要确定显着影响生存率的粘液表皮样癌的临床特点。设计:回顾性研究方法:对2003年至2011年在华中科技大学同济医学院口腔医学中心颌面外科治疗的40例患者进行回顾性临床分析。其临床特征、病理分级和生存率之间的关系所用到的统计方法是Kaplan-Meier生存分析和log-rank检验。结果:5年存活率和无瘤生存率分别是80.8%和60.7%。在单变量统计学分析时,影响生存率的显著性因素是是患者的年龄、T地位、N现状、临床分期和病理分级;影响无瘤生存率的显着因素是患者的年龄和组织学分级。结论:在我们的研究中,我们发现患者的年龄和组织学分级对生存率有重要影响。手术的目标是完整的切除病区,高级别的粘液表皮样癌应该辅助放疗,同时可以降低中分化的和低分化的粘液表皮样癌的复发。关键词:唾液腺,粘液表皮样癌ABSTRACTBackground:MECisamostcommonmalignancyaffectingthemajorandminorsalivarygland.Thepurposeofourstudywastodetermin
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