ema、vimtin、cd34、ki-67蛋白在肾细胞癌中的表达及其临床意义-expression and clinical significance of ema, vim tin, cd34 and ki - 67 protein in renal cell carcinoma.docxVIP

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ema、vimtin、cd34、ki-67蛋白在肾细胞癌中的表达及其临床意义-expression and clinical significance of ema, vim tin, cd34 and ki - 67 protein in renal cell carcinoma.docx

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ema、vimtin、cd34、ki-67蛋白在肾细胞癌中的表达及其临床意义-expression and clinical significance of ema, vim tin, cd34 and ki - 67 protein in renal cell carcinoma

TheclinicalsignificanceofEMA,Vimtin,CD34andKi-67proteinexpressioninrenalcellcarcinomaABSTRACTObjectiveDiscussionontheexpressionofEMA,Vimtin,CD34andKi-67proteininrenalcellcarcinomaandtheirclinicalsignificance.MethodRetrospectivelyanalyzedtheimmunohistochemicaldataof50casesrenalcellcarcinomaand10casesrenalangiomyolipomatoexplorethecorrelationwithclinicalpathologicalfeatures，followedupthesepatients,andanalysedtherelationbetweentheseproteinexpressionandtumorprognosis.ResultsBetweentherenalcellcarcinomagroupandtherenalangiomyolipomagroup,theexpressionlevelofEMAandVimtinproteinwerenosignificantdifference.TheproteinexpressionlevelofCD34,Ki-67inrenalcellcarcinomawerehigherthanthatinrenalangiomyolipoma.TherewerenosignificantdifferenceinEMA,Vimtinproteinexpressioninthediameter≤4cmrenalcellcarcinomagroupanddiameter4cmgroup.TheexpressionofCD34andKi-67proteinindiameter4cmgroupweresignificantlyhigherthanthatinthediameter≤4cmgroup.Andtheexpressionlevelinhighstagecancerwerehigherthanthatinlowstagecancer.ConclusionEMA,Vimtinproteinexpressionareirrelevanttotumorstageandsizeinrenalcellcarcinoma.TheexpressionOfCD34andKi-67proteininrenalcellcarcinomaarecloselyrelatedtotumorstageandtumorsize,CD34andKi-67proteincanbeusedasanimportantmolecularmarkerstoevaluateprognosisofrenalcellcarcinoma.Keywordsrenalcellcarcinoma,epithelialmembraneantigen,Vimtin,CD34,Ki-67protein中英文缩略词表RCCRCCCrenalcellcarcinomarenalclearcellcarcinoma肾细胞癌肾透明细胞癌IHCimmunohistochemistry免疫组织化学PBSphosphatebufferedsaline磷酸盐缓冲液MIUmillioninternationalunits百万国际单位EMAepithelialmembraneantigen上皮膜抗原目录一、正文····································································································1前言······························································································1材料与方法···················································································4结果······························································································7讨论····················································