顺食汤防治急性放射性食管炎临床研究.docVIP

顺食汤防治急性放射性食管炎临床研究 　　[摘要]目的：观察中药组方顺食汤对急性放射性食管炎的防治效果。方法：将267例确诊为食管癌并行放射治疗的患者随机分为研究组和对照组。研究组自放疗开始前1周服用顺食汤剂（25 ml/次，3次/d），出现急性放射性食管炎后加量（50 ml/次，3次/d）。对照组只在出现急性放射性食管炎时使用抗生素、激素治疗。两组病例均采用60Co-γ射线或6 MV-X射线加速器照射，放疗剂量＞50 Gy。结果：研究组急性放射性食管炎发生时间为放疗后（20.7±0.4）d，较对照组（17.3±0.3） d明显推迟(P＜0.05）；研究组和对照组急性放射性食管炎发生率分为23.4%和44.6%(P＜0.05)；研究组和对照组发生急性放射性食管炎后的治疗总有效率分别分为90.6%和70.7%(P＜0.05）；研究组和对照组放疗后近期有效率（CR+PR）分别为90.5%和76.2%(P＜0.05）。结论：顺食汤能推迟放射性食管炎的发生时间，明显降低发生率，提高了近期疗效，改善了病人生存质量，对急性放射性食管炎有一定防治作用。 　　[关键词]食管炎；放射性；放射防护剂；疗效 　　[中图分类号]R571[文献标识码]B [文章编号]1673-7210（2007）11（b）-036-03 　　 　　Clinical study on the prevention and cure effect of Shunshi Decoction 　　HE Fang-xue 　　(Linyi Municipal Cancer Hospital of Shandong Province,Linyi 276001,China) 　　[Abstract]Objective:To investigate the effect of Shunshi decoction for acute radioaction esophagitis. Methods:267 patients with esophagus cancer by radiotherapy using 60Co-γ ray or 6 MV X-ray with a total dose ＞50 Gy were randomly divided into the treatment group and the control group according to the time of acceptance. All parameters of the two groups were basically similar and comparable. The treatment group was given Shunshi decoction(25 ml per time, three times a day) from a week before radiotherapy, and the treatment group took more(50 ml per time, three times a day) when esophagitis taken. The control group was given antibiotic and hormone when acute radioaction esophagitis taken. Results：The commencement time of acute radioaction esophagitis of the the treatment group was(20.7±0.4)days, and the one of the control group was (17.3±0.3)days. The rate of acute radioaction esophagitis of the treatment group was 23.4%,and the one of the the control group was 44.6%. The rate of total curement of the the treatment group was 90.6%,and the one of the control group was 70.7%. The CR+PR response rate of the treatment group and the control group was 90.5% and 76.2% respectively.The difference of all the above between the two groups was significant(P＜0.0