帕瑞昔布钠对经尿道前列腺切除术镇痛和安全性分析.docVIP

帕瑞昔布钠对经尿道前列腺切除术镇痛和安全性分析 　　[摘要] 目的 评价帕瑞昔布钠用于经尿道前列腺切除术的术后镇痛和安全性。方法 将我院60例腰硬联合麻醉下行经尿道前列腺切除术的患者随机分为A组和B组。A组患者在麻醉诱导前30 min快速静脉注射溶解于2 mL生理盐水的40 mg帕瑞昔布钠；B组患者在麻醉诱导前30 min快速经脉注射2 mL生理盐水。记录术后30 min（T1），术后1 h（T2）、2 h（T3）、4 h（T4）和6 h（T5）的VAS 评分，手术前和术后血红蛋白水平以及凝血功能指标（凝血酶原时间PT，国际标准化比率INR）。 结果 A组在术后T1、T2、T3、T4和T5 时间点的 VAS 评分均低于B组（P 　　[关键词] 帕瑞昔布钠；术后镇痛；安全性 　　[中图分类号] R697.3 [文献标识码] A [文章编号] 1673-7210（2012）04（a）-0099-02 　　 　　Analgesic efficacy and safety of Parecoxib Sodium after transurethral resection of prostate 　　ZHAN Leyun DENG Caiying SHU Aihua ZHANG Mingyu CHEN Xiaobo▲ 　　Department of Anesthesiology, the First Peoples Hospital of Yichang City, Hubei Province, Yichang 443000, China 　　[Abstract] Objective To assess the analgesic efficacy and safety of Parecoxib Sodium after transurethral resection of prostate. Methods 60 patients undergoing transurethral resection of prostate under spinal combined epidural anesthesia were randomly divided into group A and group B. Patients of group A were intravenous injected 40 mg Parecoxib Sodium that was dissolved in 2 mL Normal Saline before anesthesia induction 30 min. Patients of group B were intravenous injected 2 mL Normal Saline before anesthesia induction 30 min. Postoperative pain scores were evaluated at 30 min, 1, 2, 4 and 6 hours after administration of each Analgesic, using a visual analogue scale (VAS). Furthermore, preoperative and postoperative hemoglobin (Hb) levels and hemostatic variables [prothrombin time (PT) and the international normalized ratio (INR)] were recorded in all patients. Results The score of VAS of group A at the time of T1, T2, T3, T4, T5 were lower than that of group B, there were significant decreases (P 　　1.4 统计学方法 　　采用SPSS 10.0统计学软件进行分析，计量资料以均数±标准差（x±s） 表示，不同时点组间比较采用单因素重复测量数据方差分析，计数资料采用χ2检验。以P 0.05）。见表2。 　　 　　表2 两??手术前后血红蛋白水平以及凝血功能指标比较（x±s） 　　 　　 　　 　　 　　 　　 　　 　　2.3 两组不良反应比较 　　术后2 h恶心呕吐发生情况分别为A组3例（10%），B组2例（7%）；A组有1例患者发生较轻程度的过敏反应，B组则没有。两组均无便秘、瘙痒等其他不良反应，未出现心律失常、呼吸抑制、肾功能